Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 January 1998

Retrospective and prospective analysis of chosen factors influencing the development of diabetic nephropathy

Maryna Krawczuk-Rybak, Jadwiga Peczyńska, Mirosława Urban

Med Sci Monit 1998; 4(6): EP1030-1035 :: ID: 451792


The aim of this study was to identify factors preceding and influencing the development of diabetic nephropathy,from normo- to microalbuminuria. Retrospective analysis was carried out on a group of 15 young patients with type I diabetes mellitus (mean age - 16.6 years, SD - 1.34) and persistent microalbuminuria which had appeared at a mean age of 14.9 years, SD - 1.6 (during the period '-3', '-2', '-1' years preceding the appearance of permanent microalbuminuria and at the moment of its manifestation - ' period 0'). We also carried out a prospective evaluation of the following indices nearly two years following the appearance of microalbuminuria (period '+1'): body mass index (BMI), arterial pressure values, daily insulin dosage per body mass (kg), glycemic control (HbA1c) and lipid balance. The control group comprised 13 diabetes mellitus patients with no microangiopathy symptoms (same disease duration time).
Results: 1. The systolic arterial pressure was higher in the studied group in comparison with the control group during microalbuminuric symptoms ('0'), while the diastolic arterial pressure during the period '-3'. Analysis of other periods showed no differences. 2. HbA1c and daily insulin dose values were elevated in all periods of our analysis. 3. We noted no differences in BMI values. 4. Total cholesterol values did not differ, while triglyceride values were found to be elevated during retrospective analysis.
Conclusion: The appearance of microalbuminuria is preceded by long-term incorrect glycemic control, administration of increased insulin doses and a tendency towards higher triglycerides values.

Keywords: Diabetes Mellitus, complications, diabetic nephropathy, dyslipidemia

Add Comment 0 Comments


01 May 2024 : Editorial  

Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)

Dinah V. Parums

DOI: 10.12659/MSM.944927

Med Sci Monit 2024; 30:e944927

In Press

17 Mar 2024 : Clinical Research  

Protective Role of TRPC3 Gene Polymorphism (rs10518289) in Obstructive Sleep Apnea Hypopnea Syndrome Among ...

Med Sci Monit In Press; DOI: 10.12659/MSM.942667  


27 Mar 2024 : Clinical Research  

Impact of Patient Education Formats on Treatment Adherence and Denture Hygiene in Edentulous Patients: A Co...

Med Sci Monit In Press; DOI: 10.12659/MSM.944175  

27 Mar 2024 : Clinical Research  

Incidence, Risk Factors, and Outcomes of Left Atrial Enlargement in Patients Requiring Right Ventricular Pa...

Med Sci Monit In Press; DOI: 10.12659/MSM.944114  

15 May 2024 : Database Analysis  

MRTO4 Enhances Glycolysis to Facilitate HCC Progression by Inhibiting ALDOB

Med Sci Monit In Press; DOI: 10.12659/MSM.944685  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750