01 July 2006
Lymphotoxin-alpha and cardiovascular disease: Clinical association and pathogenic mechanisms.Joseph J. Naoum, Hong Chai, Peter H. Lin, Alan B. Lumsden, Qizhi Yao, Changyi Chen
Med Sci Monit 2006; 12(7): RA121-124 :: ID: 452214
Inflammation plays an important role in atherosclerotic plaque formation,rupture and thrombogenicity. Many cytokines are the most important biomediates of inflammation and itsassociated vascular lesions. Lymphotoxin-alpha (LTalpha) is part of the tumor necrosis factor (TNF) familyof cytokines that mediates an inflammatory or immunologic response that can affect cell death or differentiation,and provide an important link of communication between lymphocytes and stromal cells. Several geneticand clinical studies implicate LTalpha, and its binding and regulatory partner galectin-2, as a riskfactor in the pathogenesis of cardiovascular diseases including miocardial infarction, aortic aneurysm,and cerebral infarction. The LTalpha gene variability is also associated with an increased level of C-reactiveprotein, an inflammatory marker. In knockout mice, loss of LTalpha leads to a reduction of atheroscleroticlesion size. Together, these findings support the cytokine LTalpha as a mediator of inflammation andits association with the pathogenesis of cardiovascular disease. However, the molecular mechanisms ofLTalpha -induced cellular responses are largely unknown. Preliminary studies indicate that the combinationof LTalpha subunits, specific interaction with its potential receptors and other cytokines, and signaltransduction pathways may significantly contribute to the overall effects of LTalpha on the inflammation,gene expression, and functions of cardiovascular cells. More clinical and basic science studies are warrantedto further understand the role of LTalpha in cardiovascular disease.
Keywords: Cell Differentiation - physiology, Cell Death - physiology, Cardiovascular Diseases - physiopathology, Lymphotoxin-alpha - physiology
01 March 2023 : EditorialEditorial: Global Surveillance of Highly Pathogenic Avian Influenza Viruses in Poultry, Wild Birds, and Mammals to Prevent a Human Influenza Pandemic
Med Sci Monit 2023; 29:e939968
03 March 2023 : Database AnalysisReinfections from SARS-CoV-2: A Retrospective Study from the Gyncentrum Genetic Laboratory in Sosnowiec, Po...
Med Sci Monit In Press; DOI: 10.12659/MSM.939452
09 February 2023 : Clinical ResearchEvaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...
Med Sci Monit 2023; 29:e938892
19 January 2023 : Clinical ResearchDetermining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...
Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical ResearchEffect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...
Med Sci Monit 2022; 28:e938926
19 Mar 2023 : Clinical ResearchManagement of Unstable C1 Fractures Involving the Lateral Mass: Posterior C1-C2 Screw-Rod Fixation and Fusion
Med Sci Monit In Press; DOI: 10.12659/MSM.938600
17 Mar 2023 : Clinical ResearchRelationship Between Autonomic Nervous System Activity and Axial Length in Children
Med Sci Monit In Press; DOI: 10.12659/MSM.939451
15 Mar 2023 : Clinical ResearchRelationship Between Psychological Symptoms and Self-Esteem Levels Before and After Stomach Botox Treatment
Med Sci Monit In Press; DOI: 10.12659/MSM.939618
15 Mar 2023 : Clinical ResearchShort-Term Patient Outcomes Using the Interlaminar Endoscopic Surgical System Ilessys® Delta System versus ...
Med Sci Monit In Press; DOI: 10.12659/MSM.938477
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952