Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 October 2006

Short term lead exposure induces a stress-like response in adult mice

Fernando Emilio Nieto-Fernandez, Adriana Ruiz, Ndidi Ntukogu, Lilian Nodimelle, Steve C. Pryor

Med Sci Monit 2006; 12(10): BR325-329 :: ID: 459174


Background: Developmental and perinatal lead exposure in rats affects the Hypothalamus-Pituitary-Adrenal
Cortex (HPA) axis function resulting in elevated corticosterone blood levels thus affecting the level
of stress responsivity of the offspring. The majority of the studies on lead exposure and stress
have been done by exposing the animal indirectly during gestation, or lactation periods. This study
presents evidence supporting that short term lead exposure affects a stress-like response in adult
lead-exposed mice.
Material/Methods: DBA/2J mice were exposed to three different lead concentrations, 250, 500 and 1000 ppm, in the drinking water for a two week period. After the exposure period the animals were subjected to behavioral tests, i.e., social contact, and the plus maze using a computer-assisted videomonitoring system,
Videomex-V (Columbia Instruments). The levels of ACTH and corticosterone in plasma were also measured using a Radioimmunoassay (RIA).
Results: Exposed animals displayed a signifi cant decrease in the length of time the mice pairs spent within social contact distance (5.18±0.58 seconds for controls and 3.23±0.34 seconds for 1000 ppm exposure),
and a signifi cant decrease in the percent of time the mice stayed in the open arms of the plus maze (7% for controls and 1% for 1000 ppm exposure) a measure indicator of anxiety. In addition exposed mice showed increased blood levels of ACTH (573±106 μg/dL for 1000 ppm and 127±25 μg/dL for control mice) and corticosterone (195.12±52.47 controls and 87.33±10.94 for exposed).
Conclusions: These results support the hypothesis that exposure to lead of the adult mice affects a behavioral and hormonal response consistent with stress.

Keywords: Anxiety - psychology, Adrenocorticotropic Hormone - blood, Behavior, Animal - drug effects, Corticosterone - blood, Dose-Response Relationship, Drug, Lead - pharmacology, Mice, Inbred DBA, Stress, Psychological - psychology, Time Factors



01 February 2023 : Editorial  

Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939580

Med Sci Monit 2023; 29:e939580


19 January 2023 : Clinical Research  

Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...

Med Sci Monit In Press; DOI: 10.12659/MSM.938892  

27 December 2022 : Clinical Research  

Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...

Med Sci Monit 2022; 28:e938926

10 December 2022 : Clinical Research  

Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...

Med Sci Monit 2022; 28:e938647

In Press

06 Feb 2023 : Clinical Research  

Double C-Arm Digital Subtraction Angiography Guidance During Transjugular Intrahepatic Portosystemic Shunt ...

Med Sci Monit In Press; DOI: 10.12659/MSM.938912  

06 Feb 2023 : Review article  

Evolution of Hybrid Intelligence and Its Application in Evidence-Based Medicine: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.939366  

03 Feb 2023 : Clinical Research  

Treatment of Gingival Recession Defects with Pouch and Tunnel Technique Using Connective Tissue Graft and L...

Med Sci Monit In Press; DOI: 10.12659/MSM.938865  

02 Feb 2023 : Clinical Research  

Online Questionnaire-Based Study to Evaluate the Attitudes and Use of Rubber Dental Dams by Saudi Dental Pr...

Med Sci Monit In Press; DOI: 10.12659/MSM.938672  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750