Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

17 March 2003

Bacterial adhesins and the role of sialic acid in bacterial adhesion.

Serhan Sakarya, Serkan Öncü

Med Sci Monit 2003; 9(3): RA76-82 :: ID: 4713


Bacterial infection, which basically starts when the microorganism binds to certain host cells, is a multi-factorial process that can be subdivided into distinct stages. To initiate infection, pathogens must first be able to colonize an appropriate host target tissue. Colonization begins
with attachment. The primary stage of infection is modulated by specific molecules on both the pathogens and the host cells. The bacterial factors are often called adhesins, and the host cell factors are receptors. The initial contact between adhesins and receptors always involves biophysical and biochemical interactions. Although adhesin proteins and bacterial lectins are the most common functional elements of adhesins, the carbohydrate content of receptors is
their most functional part. Blocking the primary stage of infection may be the most effective strategy to prevent bacterial infections. Although adhesin-based vaccine studies have been demonstrated to protect against infections, the large number of bacterial adhesin structures
would necessitate the development of a different vaccine for each bacteria. In contrast, most of the adhesin receptors on eukaryotic cells are rich in carbohydrates, and many of these carbohydrate
moieties are rich in sialic acid, although some of them are not well defined. Thus receptor carbohydrate moieties and their sialic acid content may be key targets in this strategy.

Keywords: Adhesins, Bacterial - physiology, Bacterial Vaccines - isolation & purification, Gram-Negative Bacteria - pathogenicity, Gram-Negative Bacteria - physiology, Gram-Positive Bacteria - immunology, Gram-Positive Bacteria - pathogenicity, Gram-Positive Bacteria - physiology, N-Acetylneuraminic Acid - physiology, Receptors, Immunologic - physiology

Add Comment 0 Comments


01 February 2024 : Editorial  

Editorial: Global Health Concerns as Vaccine-Preventable Infections Including SARS-CoV-2 (JN.1), Influenza, Respiratory Syncytial Virus (RSV), and Measles Continue to Rise

Dinah V. Parums

DOI: 10.12659/MSM.943911

Med Sci Monit 2024; 30:e943911


In Press

02 Jan 2024 : Clinical Research  

Urinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender Differences in GST-pi Excretion

Med Sci Monit In Press; DOI: 10.12659/MSM.942819  


29 Dec 2023 : Clinical Research  

Performance of Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) in Chinese Population with Prima...

Med Sci Monit In Press; DOI: 10.12659/MSM.942747  

08 Jan 2024 : Review article  

Review of Approaches to the Management of Vertical Dental Root Fractures and Tooth Preservation

Med Sci Monit In Press; DOI: 10.12659/MSM.943100  

03 Jan 2024 : Clinical Research  

Comparative Efficacy of Ultrasound-Guided Cervical Fascial Infiltration versus Periarticular Administration...

Med Sci Monit In Press; DOI: 10.12659/MSM.942044  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750