Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 March 2007

A parasite vector-host epidemic model for TSE propagation

Tuen-Wai Ng, Gabriel Turinici, Wai-Ki Ching, Si-Kit Chung, Antoine Danchin

Med Sci Monit 2007; 13(3): BR59-66 :: ID: 475506

Abstract

Background: Transmissible spongiform encephalopathies (TSEs) are a family of diseases that infect mammals. They are explained by cross-contamination through an unknown route or from infection of food contaminated with prion proteins (PrPs), natural proteins that take an infectious form contributing to the slow destruction of the animal brain. While the extreme resistance of PrPs to denaturation and proteolysis accounts for a route from the mouth to the brain, the possible role of another route of contamination is explored here. Many diseases are spread by vectors, as seen in plague, typhus, malaria, or dengue. The situation where PrPs would be transmitted by a vector and, from
the characteristics of outbreaks, proposed hypotheses about the biological nature of such vectors are explored.
Material/Methods: The nontrivial situation where contamination by the vector prevents infection by making the host immune to further vector contamination was analyzed. To investigate the nature of a possible vector, the spread of a disease in a closed population of hosts and vectors where the number of hosts is constant and the vectors multiply in the host was modeled mathematically. In this model, the disease is caused by an infective agent and is spread by a vector, while direct host-to-host spread is not permitted.
Results: Concrete values of the parameters of the model were computed from simulation of the BSE outbreak in the UK as a possible example of the process.
Conclusions: Microbial vector-borne diseases might play an unexpected role in the spread of epidemics, warranting further exploration.

Keywords: Disease Outbreaks, Cattle, Disease Vectors, Great Britain - epidemiology, Host-Parasite Interactions, Models, Biological, Parasites - physiology, Prion Diseases - veterinary, Time Factors

0 Comments

Editorial

01 February 2023 : Editorial  

Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939580

Med Sci Monit 2023; 29:e939580

SARS-CoV-2/COVID-19

19 January 2023 : Clinical Research  

Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...

Med Sci Monit In Press; DOI: 10.12659/MSM.938892  

27 December 2022 : Clinical Research  

Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...

Med Sci Monit 2022; 28:e938926

10 December 2022 : Clinical Research  

Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...

Med Sci Monit 2022; 28:e938647

In Press

03 Feb 2023 : Clinical Research  

Treatment of Gingival Recession Defects with Pouch and Tunnel Technique Using Connective Tissue Graft and L...

Med Sci Monit In Press; DOI: 10.12659/MSM.938865  

02 Feb 2023 : Clinical Research  

Online Questionnaire-Based Study to Evaluate the Attitudes and Use of Rubber Dental Dams by Saudi Dental Pr...

Med Sci Monit In Press; DOI: 10.12659/MSM.938672  

02 Feb 2023 : Database Analysis  

Prognostic-Related Biomarkers in Pancreatic Ductal Adenocarcinoma Correlating with Immune Infiltrates Based...

Med Sci Monit In Press; DOI: 10.12659/MSM.938785  

01 Feb 2023 : Clinical Research  

Comparison of 3 Enzyme-Linked Immunoassay Methods to Evaluate Serum Concentrations of Infliximab and Antibo...

Med Sci Monit In Press; DOI: 10.12659/MSM.939084  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750