Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

30 March 2007

High peak inspiratory flow can aggravate ventilator-induced lung injury in rabbits

Yasuki Fujita, Yuji Fujino, Akinori Uchiyama, Takashi Mashimo, Masaji Nishimura

Med Sci Monit 2007; 13(4): BR95-100 :: ID: 480297


Background: The study investigated the effect of peak inspiratory flow in a rabbit acute lung injury model.
Material and methods: Twenty-five male rabbits were anesthetized and mechanically ventilated with high tidal volume (V<sub>T</sub>) until PaO<sub>2</sub> dropped below 300 mmHg. Then the animals were randomly assigned to two groups: group V (n=10) receiving volume-control ventilation and group P (n=10) receiving pressure-regulated volume-control ventilation. Each animal was ventilated for 8 h at the following settings: V<sub>T</sub> 20 ml/kg, positive end-expiratory pressure 5 cm H<sub>2</sub>O, and respiratory rate 20 breaths/min with inspiratory-to-expiratory ratio of 1:4. Whether eleven hours of pressure-regulated volume-control ventilation at a V<sub>T</sub> of 20 ml/kg was harmful in rabbits with healthy lungs (control group, n=5) was also investigated.
Results: Group P’s peak inspiratory flow was significantly (<i>p</i><0.05) higher than group V’s. From 4 h after the establishment of acute lung injury to the end of the experiment, group V’s PaO<sub>2</sub> values were significantly higher than group P’s. Wet-to-dry ratio and upper lobe tissue injury scores were higher in group P than in group V. Control animals showed neither apparent lung injury after 11 h of mechanical ventilation nor deterioration in gas exchange during the protocol.
Conclusions: Compared with volume-control ventilation with V<sub>T</sub> (20 ml/kg), pressure-regulated volume-control ventilation with the same V<sub>T</sub> worsened oxygenation, histological injury score in upper lobes, and wet-to-dry ratio in rabbits with injured lungs. The evidence suggests that greater deterioration in gas exchange and lung injury is associated with high inspiratory flow.

Keywords: Lung - physiopathology, Analysis of Variance, Lung Injury, Positive-Pressure Respiration - adverse effects, Pressure, Respiratory Mechanics - physiology, Tidal Volume

Add Comment 0 Comments


01 April 2024 : Editorial  

Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug Resistance

Dinah V. Parums

DOI: 10.12659/MSM.944600

Med Sci Monit 2024; 30:e944600


In Press

06 Mar 2024 : Clinical Research  

Enhanced Surgical Outcomes of Popliteal Cyst Excision: A Retrospective Study Comparing Arthroscopic Debride...

Med Sci Monit In Press; DOI: 10.12659/MSM.941102  

06 Mar 2024 : Clinical Research  

Prevalence and Variation of Medical Comorbidities in Oral Surgery Patients: A Retrospective Study at Jazan ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943884  

08 Mar 2024 : Clinical Research  

Evaluation of Foot Structure in Preschool Children Based on Body Mass

Med Sci Monit In Press; DOI: 10.12659/MSM.943765  

15 Apr 2024 : Laboratory Research  

The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in Osteoarthritis

Med Sci Monit In Press; DOI: 10.12659/MSM.943738  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750