30 March 2007
Gender-specific comparison of five QT correction formulae in middle-aged participants in an atherosclerosis prevention program
Bernhard Strohmer, Christiana Christiana Schernthaner, Bernhard Paulweber, Maximilian PichlerMed Sci Monit 2007; 13(4): CR165-171 :: ID: 481097
Abstract
Background: Analysis of QT duration limited to a single heart rate correction formula might be problematic in cross-sectional studies. The aim of this study was to investigate five frequently used equations with respect to over- and under-correction of QT intervals in a middle-aged population without manifest atherosclerotic disease.
Material and Methods: A total of 1199 individuals (851 males, 348 females, aged 39 to 66 years) of the SAPHIR study (Salzburg Atherosclerosis Prevention Program in Subjects at High Individual Risk) were investigated. Heart rate, RR, and QT intervals were measured automatically from resting ECGs with the 12SL™ ECG Analysis Program (GE Medical Systems). Five methods (Bazett, Fridericia, Framingham, Hodges, and Rautaharju) were used to correct the QT interval for heart rate.
Results: Females had shorter RR intervals than males (963±141 vs. 1022±158 ms, <i>p</i><0.0005), with longer QT (410±28 vs. 404±28 ms, <i>p</i>=0.003) and QTc intervals using all five formulae (<i>p</i><0.0005). No significant differences were observed between the gender groups for the QTc/RR slopes regardless of the formula. The Bazett formula performed the worst and the Fridericia the best in terms of rate adjustment success (slope B=–0.001). The optimal alpha of the best-fit equation (QTc=QT/RR<sup>α</sup>) was calculated as 0.326 for males and 0.328 for females.
Conclusions: These results demonstrate that automatic QT measurements can be used reliably in cardiovascular prevention programs, encouraging further investigation of their clinical value in risk stratification. From an epidemiological perspective, however, the selected QT correction formula applied to a specific population has to be evaluated for appropriateness.
Keywords: Atherosclerosis - prevention & control, Austria, Electrocardiography - methods, Heart Rate - physiology, Regression Analysis, Sex Factors
Editorial
01 April 2025 : Editorial
Editorial: Rapid Testing for the Avian Influenza A(H5N1) Virus is Urgently Required as Infections in Poultry and Dairy Cows are on the Rise, and so is Transmission to HumansDOI: 10.12659/MSM.949109
Med Sci Monit 2025; 31:e949109
In Press
Review article
Global Guidelines and Trends in HPV Vaccination for Cervical Cancer PreventionMed Sci Monit In Press; DOI: 10.12659/MSM.947173
Clinical Research
Serum Prolidase and Ischemia-Modified Albumin Levels in Neural Tube Defects: A Comparative Study of Myelome...Med Sci Monit In Press; DOI: 10.12659/MSM.947873
Clinical Research
Impact of Depression, Fatigue, and Pain on Quality of Life in Slovak Multiple Sclerosis PatientsMed Sci Monit In Press; DOI: 10.12659/MSM.947630
Clinical Research
Longitudinal Evaluation of Metabolic Benefits of Inactivated COVID-19 Vaccination in Diabetic Patients in T...Med Sci Monit In Press; DOI: 10.12659/MSM.947450
Most Viewed Current Articles
17 Jan 2024 : Review article 7,960,158
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research 702,953
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Mar 2024 : Editorial 29,945
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ...DOI :10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
28 Jan 2024 : Review article 23,915
A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and FutureDOI :10.12659/MSM.943912
Med Sci Monit 2024; 30:e943912