Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 January 1996

Bone formation markers and parathormone levels in children with end-stage renal disease during the early period of growth hormone treatment

Maria Sieniawska, Małgorzata Pańczyk-Tomaszewska, Paweł Grzesiowski

Med Sci Monit 1996; 2(1): CR77-81 :: ID: 499526


The aim of the study was to estimate the changes in bone formation markers (procollagen lC - PICP0, osteocalcin - OC, alkaline phosphatase - AP) and parathormone (PTH intact) in children with end-stage renal disease during the first 6 months of recombinant human growth hormone (rhGH) treatment. 13 children, aged 6-13 years were included in the study, 7 on haemodialysis (HD) and 6 on continuous ambulatory peritoneal dialysis (CAPD). The patients received rhGH (1-1.1 IU/kg/week s.c.), alfacalcidol (0.038-0.13 mg/kg body weight/week) and calcium carbonate (50-150 mg/kg body weight/day). Morphometric analysis of iliac crest bone performed in 12 children prior to rhGH treatment revealed osteitis fibrosa in 1 case (8.3%), mild lesion of secondary hyperparathyroidism in 8 cases (66.8%), adynamic bone disease in 1 case (8.3%) and normal histology in 2 (16.6%). The height increment after 6 months was 3.2-5.9 cm in 11 children and 0.8 cm in 1 child. In the first 3 months of treatment the PICP concentrations increased in 11 children, but the OC levels increased in 5 children only. After 6 months the OC levels increased in 11 children. The AP activity increased in 9 out of 13 patients. In 7 children the levels of intact PTH were 7 to 24 times higher that the baseline levels, exceeding 200 mg/ml. The increased PTH levels were probably the result of inadequate dosage of vitamin D active metabolite in children with improved growth velocity.

Keywords: end-stage renal disease, recombinant human growth hormone, parathormone, osteocalcin, procollagen lC

Add Comment 0 Comments


01 May 2024 : Editorial  

Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)

Dinah V. Parums

DOI: 10.12659/MSM.944927

Med Sci Monit 2024; 30:e944927

In Press

07 May 2024 : Clinical Research  

Treatment of AVN-Induced Proximal Pole Scaphoid Nonunion Using a Fifth and Fourth Extensor Compartmental Ar...

Med Sci Monit In Press; DOI: 10.12659/MSM.944553  

16 Mar 2024 : Clinical Research  

Diagnostic Efficiency of ACR-TIRADS Score for Differentiating Benign and Malignant Thyroid Nodules of Vario...

Med Sci Monit In Press; DOI: 10.12659/MSM.943228  

08 May 2024 : Clinical Research  

Effect of Individualized PEEP Guided by Driving Pressure on Diaphragm Function in Patients Undergoing Lapar...

Med Sci Monit In Press; DOI: 10.12659/MSM.944022  

21 Mar 2024 : Clinical Research  

Impact of Serum Vitamin D, B6, and B12 and Cognitive Functions on Quality of Life in Peri- and Postmenopaus...

Med Sci Monit In Press; DOI: 10.12659/MSM.943249  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750