Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 May 1996

Selected elements of the pathogenesis of pruritus in haemodialysis patients the own study

Jacek Szepietowski

Med Sci Monit 1996; 2(3): HY343-347 :: ID: 499885


Etiopathogenesis of uraemic pruritus remains unclear. In the present study, including 119 chronic haemodialysis patients, the correlation between pruritus and methods of haemodialysis and associated metabolic abnormalities was evaluated. In addition in 32 patients cutaneous mast cells were studied using enzymocytochemical methods. Pruritus was found in 58.8% of the patients. In the pruritic haemodialysis patients serum calcium concentrations were significantly increased. Moreover, serum phosphorus concentrations were also evidently elevated in the patients with pruritus. Pruritus was found to be more common in patients with a longer haemodialysis period and in patients haemodialysed using less permeable cuprophane dialyzers compared to those dialysed using polysulphone dialyzers. No correlation was demonstrated between the frequency and intensity of pruritus and the type of dialysate, erythropoietin intake, age and sex of patients, underlying renal disease, degree of anaemia and serum concentrations of urea, creatinine, sodium, potassium, magnesium, parathormone and alkaline phosphatase. In the haemodialysis patients the mean number of cutaneous mast cells was significantly higher compared to healthy individuals. No correlation was found with the number of mast cells and duration of haemodialysis period, the serum concentrations of calcium, phosphorus, magnesium and parathormone. In the pruritic patients mast cells were only slightly more numerous than in nonpruritic subjects, although in the patients suffering from pruritus the percentage of tryptase-positive chymase-positive mast cells was significantly decreased compared to nonpruritic individuals. This can play an important role in the etiopathogenesis of pruritus in patients on maintenance haemodialysis treatment.

Keywords: uremic pruritus, haemodialysis, Mast Cells

Add Comment 0 Comments

724 0


01 November 2023 : Editorial  

Editorial: Factors Driving New Variants of SARS-CoV-2, Immune Escape, and Resistance to Antiviral Treatments as the End of the COVID-19 Pandemic is Declared

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville,

DOI: 10.12659/MSM.942960

Med Sci Monit 2023; 29:e942960


In Press

29 Nov 2023 : Laboratory Research  

CTRP13 Mitigates Endothelial Cell Ferroptosis via the AMPK/KLF4 Pathway: Implications for Atherosclerosis P...

Med Sci Monit In Press; DOI: 10.12659/MSM.942733  

28 Nov 2023 : Clinical Research  

Impact of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography on Therapeutic Decisions and ...

Med Sci Monit In Press; DOI: 10.12659/MSM.942122  

28 Nov 2023 : Clinical Research  

Long-Term Outcomes of Decompression and Grafting in Acute Pathological Proximal Femur Fractures in Children...

Med Sci Monit In Press; DOI: 10.12659/MSM.943031  

27 Nov 2023 : Clinical Research  

Comparison of Outcomes from Emergency Admissions to a Major Trauma Center in Turkey of 1646 Elderly Patient...

Med Sci Monit In Press; DOI: 10.12659/MSM.942916  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750