Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 1996

Plasma and erythrocyte malondialdehyde concentrations in children with chronic gastroduodenitis

Grażyna Bała, Mieczysława Czerwionka-Szaflarska, Gerard Drewa, Grażyna Mierzwa

Med Sci Monit 1996; 2(4): CR469-473 :: ID: 499965


Background: The mechanism of gastroduodenitis is complex and remains to be fully elucidated. Oxygen-derived free radicals and their toxic products may play a significant role in this process. The aim of the study was to find out whether the generation of highly reactive states of oxygen is increased in chronic gastroduodenitis in children.
Material/Methods: We determined plasma and erythrocyte concentrations of malondialdehyde (MDA) in 100 children aged 6 to 17 years. In all of them gastroscopy was performed and specimens of the mucosa were obtained prior to and following treatment. The patients were divided into 2 groups, i.e., with and without improvement in the mucosal status after treatment. A control group consisted of 50 children with coeliac disease on a gluten-free diet, who did not complain of abdominal pain.
Results: Prior to treatment, the mean plasma and erythrocyte MDA concentrations were significantly higher in children with chronic gastroduodentis than in controls (p < 0.001). After treatment these variables were reduced in patients who demonstrated improvement. In patients without improvement, the mean plasma and erythrocyte MDA concentrations further increased after treatment.
Conclusions: 1. Oxygen-derived free radicals are probably involved in the pathogenesis of gastroduodentis in children. 2. Measurements of plasma and erythrocyte MDA concentrations could be used to monitor the course of disease and possibly modify treatment in gastroduodentis in children.

Keywords: gastroduodentis, Malondialdehyde, Free Radicals, children



01 August 2022 : Editorial  

Editorial: Long-Term Effects of Symptomatic and Asymptomatic SARS-CoV-2 Infection in Children and the Changing Pathogenesis of Common Childhood Viruses Driven by the COVID-19 Pandemic

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.937927

Med Sci Monit 2022; 28:e937927

In Press

12 Aug 2022 : Clinical Research  

Risk Factors and Pathogen Spectrum in Continuous Ambulatory Peritoneal Dialysis-Associated Peritonitis: A S...

Med Sci Monit In Press; DOI: 10.12659/MSM.937112  

11 Aug 2022 : Meta-Analysis  

Optimal Surgical Treatment Method for Anterior Cruciate Ligament Rupture: Results from a Network Meta-Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.937118  

10 Aug 2022 : Review article  

Programmed Cell Death in Diabetic Nephropathy: A Review of Apoptosis, Autophagy, and Necroptosis

Med Sci Monit In Press; DOI: 10.12659/MSM.937766  

10 Aug 2022 : Database Analysis  

Use and Effects of Augmentation of Labor with Oxytocin: A Single-Center, Retrospective, Case-Control Study ...

Med Sci Monit In Press; DOI: 10.12659/MSM.937557  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750