Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 1996

Plasma and erythrocyte malondialdehyde concentrations in children with chronic gastroduodenitis

Grażyna Bała, Mieczysława Czerwionka-Szaflarska, Gerard Drewa, Grażyna Mierzwa

Med Sci Monit 1996; 2(4): CR469-473 :: ID: 499965

Abstract

Background: The mechanism of gastroduodenitis is complex and remains to be fully elucidated. Oxygen-derived free radicals and their toxic products may play a significant role in this process. The aim of the study was to find out whether the generation of highly reactive states of oxygen is increased in chronic gastroduodenitis in children.
Material/Methods: We determined plasma and erythrocyte concentrations of malondialdehyde (MDA) in 100 children aged 6 to 17 years. In all of them gastroscopy was performed and specimens of the mucosa were obtained prior to and following treatment. The patients were divided into 2 groups, i.e., with and without improvement in the mucosal status after treatment. A control group consisted of 50 children with coeliac disease on a gluten-free diet, who did not complain of abdominal pain.
Results: Prior to treatment, the mean plasma and erythrocyte MDA concentrations were significantly higher in children with chronic gastroduodentis than in controls (p < 0.001). After treatment these variables were reduced in patients who demonstrated improvement. In patients without improvement, the mean plasma and erythrocyte MDA concentrations further increased after treatment.
Conclusions: 1. Oxygen-derived free radicals are probably involved in the pathogenesis of gastroduodentis in children. 2. Measurements of plasma and erythrocyte MDA concentrations could be used to monitor the course of disease and possibly modify treatment in gastroduodentis in children.

Keywords: gastroduodentis, Malondialdehyde, Free Radicals, children

Add Comment 0 Comments

517 0

Editorial

01 November 2023 : Editorial  

Editorial: Factors Driving New Variants of SARS-CoV-2, Immune Escape, and Resistance to Antiviral Treatments as the End of the COVID-19 Pandemic is Declared

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville,

DOI: 10.12659/MSM.942960

Med Sci Monit 2023; 29:e942960

0:00

In Press

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.942740  

30 Nov 2023 : Clinical Research  

Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...

Med Sci Monit In Press; DOI: 10.12659/MSM.942508  

29 Nov 2023 : Clinical Research  

Comparative Analysis of Intramedullary Nail versus Plate Fixation for Fibula Fracture in Supination Externa...

Med Sci Monit In Press; DOI: 10.12659/MSM.941909  

29 Nov 2023 : Clinical Research  

Impact of COVID-19 on Academic Burnout among Medical College Students in China: Findings from a Web-Based S...

Med Sci Monit In Press; DOI: 10.12659/MSM.942317  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

0:00

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750