01 November 1996
Application of studies of nucleolar organizer regions (NORs) to clinical and morphological diagnosis, particularly in lung cancerDaniel Sabat, Jerzy K. Nożyński, Zbigniew Szczurek, Andrzej Gabriel
Med Sci Monit 1996; 2(6): CR720-726 :: ID: 500125
Expression marking of nucleolar organising regions (NORs) is a modern quantitative diagnostic method applied more widely in evaluation of proliferating activity of tumour cells. A particular interest has been observed since 1986, i.e., since a report by Ploton on a simple colloid method of one-stage protein silverstaining. This allowed a quantitative evaluation of the regions on light microscopy. The present study describes application of marking of argyrophil granules (Ag-NORs) in different tumours and precancerous stages mainly to differentiate borderline lesions. Particular emphasis is paid to the use of the granulation marking in diagnosing small and non-small cell lung carcinoma. The study presents a number of controversies on dependence of Ag-NOR expression on the histological type, clinical stage and tumour mass doubling time as well as views on little usefulness of Ag-NORs in differentiating particular types of carcinomas. Alternating study methods of granules in the cell nucleus from tissue and cytological material, the application of computer analysis and Ag-NOR method assisted by immunohistochemical techniques are also discussed.
Keywords: nucleolar organiser regions, lung cancer
01 June 2023 : EditorialEditorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness
Med Sci Monit 2023; 29:e941209
01 Jun 2023 : Clinical ResearchRoot Canal Numbers and Configurations in 1080 Permanent Canine Teeth in 270 Saudi Subjects Using Cone-Beam ...
Med Sci Monit In Press; DOI: 10.12659/MSM.940472
01 Jun 2023 : Clinical ResearchInternal Orifice Alloy Closure: A New Procedure for Treatment of Perianal Fistulizing Crohn’s Disease
Med Sci Monit In Press; DOI: 10.12659/MSM.940873
01 Jun 2023 : Clinical ResearchEffectiveness of Needle Aspiration versus Surgical Excision for Symptomatic Synovial Cysts of the Hip: A Si...
Med Sci Monit In Press; DOI: 10.12659/MSM.940187
01 Jun 2023 : Clinical ResearchInfluence of Insulin Resistance on Diabetes Nephropathy
Med Sci Monit In Press; DOI: 10.12659/MSM.939482
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952