Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 November 1996

Recovery of forced vital capacity directly correlates with reversal of benzodiazepine-induced sedation

Avi A. Weinbroum, Valery Rudick, Patrick Sorkine, Pinhas Halpern, Ron Flaishon, David Niv, Eran Geller

Med Sci Monit 1996; 2(6): CR756-763 :: ID: 500150


Background: Benzodiazepines induce sedation and depress high mental functions and respiration. We conducted a prospective, randomized double-blind study on the efficacy of flumazenil in reversing the effects of these functions and the possible relationship between them.
Material/Methods:One hundred and six ASA II-III patients, aged 61±1.6 (SEM) (ranges 20-86) years were sedated intraoperatively with IV midazolam (0.15 mgxkg-1,). All underwent urological and lower abdominal procedures under bupivacaine 0.5% epidural anesthesia. In the recovery room, mental functions, respiratory and cardiovascular indices were assessed before and after the injection of either flumazenil or saline in a randomized, double-blind manner.
Results:All mental functions were restored by 0.3±0.02 mg flumazenil within 5 min of its administration. Flumazenil-treated patients, arousable by skin stimulation only, were fully awake and calm for the 90 min of the study while the controls remained significantly (P<0.01) more sedated for 60 min. Orientation for time and space improved after flumazenil (scale 0-2, from 0.7±0.1 to 1.9±0.1, P<0.001); fine and coarse coordination became 3 times more accurate than in controls. Amnesia at 5 min was reversed in 44% vs. 8% of control patients (P<0.001). Forced vital capacity (FVC) increased after flumazenil (from 2.1±0.2 to 2.8±0.1 L, P<0.02) and correlated (Pearson correlation coefficient, rp= -0.99) significantly (P = 0.0000) with sedation score. Both younger (40±3 years) and elderly (71±1, P<0.01) patients required a similar dose of flumazenil to restore all functions, and were similar throughout study. Heart rate, blood pressure and respiratory rate did not change following flumazenil administration.

Keywords: discoordination, Flumazenil, Midazolam, sedation, Surgery, Vital Capacity

Add Comment 0 Comments

510 0


01 June 2023 : Editorial  

Editorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.941209

Med Sci Monit 2023; 29:e941209

In Press

01 Jun 2023 : Clinical Research  

Root Canal Numbers and Configurations in 1080 Permanent Canine Teeth in 270 Saudi Subjects Using Cone-Beam ...

Med Sci Monit In Press; DOI: 10.12659/MSM.940472  

01 Jun 2023 : Clinical Research  

Internal Orifice Alloy Closure: A New Procedure for Treatment of Perianal Fistulizing Crohn’s Disease

Med Sci Monit In Press; DOI: 10.12659/MSM.940873  

01 Jun 2023 : Clinical Research  

Effectiveness of Needle Aspiration versus Surgical Excision for Symptomatic Synovial Cysts of the Hip: A Si...

Med Sci Monit In Press; DOI: 10.12659/MSM.940187  

01 Jun 2023 : Clinical Research  

Influence of Insulin Resistance on Diabetes Nephropathy

Med Sci Monit In Press; DOI: 10.12659/MSM.939482  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750