Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 November 1996

High doses of alphacalcidol given once a week - a new method of treatment of uraemic secondary hyperparathyroidism

Ewa Pacocha, Joanna Matuszkiewicz-Rowińska, Stanisław Niemczyk, Marek Świtalski, Barbara Bogdańska-Straszyńska, Kazimierz Ostrowski

Med Sci Monit 1996; 2(6): CR784-788 :: ID: 500494

Abstract

High dose pulse iv or oral 1,25 (OH)2,D3,/1(αOH)D3, therapy in uremic hyperparathyroidism has been shown to be much more effective than daily standard doses. The problem of hypercalcemia, however, still exists. Since in the last years protracted fall in serum PTH was found after a single dose of 1,25 (OH)2,D3, we decided to check whether 1(αOH)D3, administrated once weekly is effective in parathyroid hyperactivity of chronic renal failure. 17 hemodialysis patients with advanced hyperparathyroidism were given oral alphacalcidol in doses of 6 (g once a week, during the dialysis session. Dialysate calcium was 1.40 - 1.45 moll/l, and CaCO3, (up to 6 g/day) was used as the main phosphate binder; in 6 patients Al(OH)3, (up to 3 g/day) was added. The doses of 1 (αOH)D3,CaCO3, and Al(OH)3, were modified according to the calcium and phosphate levels. Serum 1 - 84 PTH decreased significantly after 2 weeks (p (0.02), and then the reduction of parathyroid activity progressed to 51&plusm;6.1&percnt; at the end of the study. The normalisation of PTH secretion was seen only in one patient and the treatment was ineffective in 4 patients; 3 of them had initial serum PTH levels (800 pg/ml. The serum 1,25 (OH)2,D3, levels increased from 8.5±1.08 pg/ml to 17.0±2.72 pg/ml (p<0.025). Serum total calcium, phosphate, alkaline phosphatase activity and hydroxyproline levels did not change significantly, nor did the doses of 1α(OH)D3,CaCO3, and Al(OH)3,. The incidence of hypercalcemia was 2.6% hese results indicate that oral pulse therapy with alphacalcidol administered once a week effectively reduces PTH secretion in hemodialysis patients with moderate hyperparathyroidism, with low risk of hypercalcemia and oversuppression of parathyroid activity.

Keywords: alphacalcidol, chronic renal failure, uremic hyperparathyroidism, hemodialysis

0 Comments

Editorial

01 July 2022 : Editorial  

Editorial: World Health Organization (WHO) Variants of Concern Lineages Under Monitoring (VOC-LUM) in Response to the Global Spread of Lineages and Sublineages of Omicron, or B.1.1.529, SARS-CoV-2

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.937676

Med Sci Monit 2022; 28:e937676

SARS-CoV-2/COVID-19

27 June 2022 : Clinical Research  

Shoulder Injury Related to Vaccine Administration (SIRVA) in 16 Patients Following COVID-19 Vaccination Who...

Med Sci Monit In Press; DOI: 10.12659/MSM.937430  

27 May 2022 : Clinical Research  

Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)

Med Sci Monit 2022; 28:e936547

In Press

01 Jul 2022 : Clinical Research  

Does Early-Period Patient Dissatisfaction Turn Into Satisfaction Over Time After Total Knee Replacement?

Med Sci Monit In Press; DOI: 10.12659/MSM.936792  

30 Jun 2022 : Laboratory Research  

Bcl-2 19-kDa Interacting Protein 3 (BNIP3)-Mediated Mitophagy Attenuates Intermittent Hypoxia-Induced Human...

Med Sci Monit In Press; DOI: 10.12659/MSM.936760  

30 Jun 2022 : Clinical Research  

Antioxidant System and Ions Concentrations After Femoral Neck and Resurfacing Hip Arthroplasty

Med Sci Monit In Press; DOI: 10.12659/MSM.936335  

28 Jun 2022 : Meta-Analysis  

Urodynamics in Early Diagnosis of Diabetic Bladder Dysfunction in Women: A Systematic Review and Meta-Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.937166  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750