Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 November 1996

Comparison of efficacy of alfacalcidiol and calcitriol in the treatment of uraemic hyperparathyroidism

Joanna Matuszkiewicz-Rowińska, Stanisław Niemczyk, Ewa Pacocha, Marek Świtalski, Barbara Bogdańska-Straszyńska, Kazimierz Ostrowski

Med Sci Monit 1996; 2(6): CR789-793 :: ID: 500495


In our study we have compared efficacy of both metabolites of vitamin D3 administered in high doses in a pulsatile manner in the treatment of hyperparathyroidism secondary to uraemia. 27 chronically dialysed patients aged 19-61 were divided into two groups: Group 1 (13 subjects) in which patients were receiving 1,25(OH)D3, and Group 2 (14 subjects) treated with 1 alpha-OH-D3,. Both drugs were given orally, 3 times a week, during dialysis in a dose dependent upon serum calcium concentration (up to 5 micrograms at the highest). Apart from that our patients were given calcium carbonate and some of them also aluminium hydroxide. Calcium concentration in a dialysate was lowered to 1.40-1.45 mmol/l. Our study has shown similar efficacy of both Vitamin D3, metabolites: during 8 months of treatment with similar doses we have observed in both groups significant decrease of serum parathormone (PTH), hydroxyproline and alkaline phosphatase concentrations as well as increase in serum calcium concentration. Serum 1,25(OH)2,D3, measured before and after treatment have shown twice as high increase in its concentration (compared to the levels at the start point) in the group of patients treated with alphacalcidiol which proves it to be more effective in maintaining constant physiological levels of 1,25 (OH)2,D3, in serum.

Keywords: Calcitriol, alfacalcidiol, end stage renal failure, secondary hyperparathyroidism

Add Comment 0 Comments

504 0


01 June 2023 : Editorial  

Editorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.941209

Med Sci Monit 2023; 29:e941209

In Press

01 Jun 2023 : Clinical Research  

Root Canal Numbers and Configurations in 1080 Permanent Canine Teeth in 270 Saudi Subjects Using Cone-Beam ...

Med Sci Monit In Press; DOI: 10.12659/MSM.940472  

01 Jun 2023 : Clinical Research  

Internal Orifice Alloy Closure: A New Procedure for Treatment of Perianal Fistulizing Crohn’s Disease

Med Sci Monit In Press; DOI: 10.12659/MSM.940873  

01 Jun 2023 : Clinical Research  

Effectiveness of Needle Aspiration versus Surgical Excision for Symptomatic Synovial Cysts of the Hip: A Si...

Med Sci Monit In Press; DOI: 10.12659/MSM.940187  

01 Jun 2023 : Clinical Research  

Influence of Insulin Resistance on Diabetes Nephropathy

Med Sci Monit In Press; DOI: 10.12659/MSM.939482  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750