01 November 1996
Interleukin-10 (IL-10), interleukin-1 receptor antagonist (IL-1ra) and soluble IL-2 receptor alpha (sIL-2Ra) in ascitic and cystic fluids from pat ients with malignant and benign ovarian tumours
Magdalena Chechlińska, Agnieszka Antczak, Romuald DębskiMed Sci Monit 1996; 2(6): CR798-802 :: ID: 500497
Abstract
In our previous studies we have shown that ascitic fluids from ovarian cancer patients contain several distinct immunosuppressive activities that might correspond to the functions of interleukin-10 (IL-10), interleukin-1 receptor antagonist (IL-1ra), and soluble interleukin-2 receptor alpha (sIL-2Rα). This study was undertaken to evaluate the levels of IL-10, IL-1ra and sIL-2Rα in cystic and ascitic fluids from patients with benign ovarian neoplasms and epithelial ovarian cancers. Cystic fluids from 16 patients with benign ovarian cysts and ascitic fluids from 25 patients with ovarian cancer were assayed for IL-10, IL-1ra and sIL-2Ra by enzyme-linked immunosorbent assay (ELISA). The mean levels of IL-10, IL-1ra and sIL-2Rα both in cystic and ascitic fluids were above the mean levels determined by others in normal sera. The ascitic fluids from patients with ovarian cancer contained significantly elevated levels of IL-10 and sIL-2R, compared to cystic exudates from non-malignant tumours. The results reported here provide direct evidence that the immunosuppressive effects of both malignant and non-malignant ovarian exudates depend upon mechanisms which act at different stages of the immune response.
Keywords: interleukin-10 (IL-10), interleukin-1 receptor antagonist (IL-1ra), soluble IL-2 receptor alpha (sIL-2Ra), Cytokines, ovarian tumours, ascitic fluids
640 0
Editorial
01 June 2023 : Editorial
Editorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic PreparednessDOI: 10.12659/MSM.941209
Med Sci Monit 2023; 29:e941209
In Press
01 Jun 2023 : Clinical Research
Root Canal Numbers and Configurations in 1080 Permanent Canine Teeth in 270 Saudi Subjects Using Cone-Beam ...Med Sci Monit In Press; DOI: 10.12659/MSM.940472
01 Jun 2023 : Clinical Research
Internal Orifice Alloy Closure: A New Procedure for Treatment of Perianal Fistulizing Crohn’s DiseaseMed Sci Monit In Press; DOI: 10.12659/MSM.940873
01 Jun 2023 : Clinical Research
Effectiveness of Needle Aspiration versus Surgical Excision for Symptomatic Synovial Cysts of the Hip: A Si...Med Sci Monit In Press; DOI: 10.12659/MSM.940187
01 Jun 2023 : Clinical Research
Influence of Insulin Resistance on Diabetes NephropathyMed Sci Monit In Press; DOI: 10.12659/MSM.939482
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952