Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 May 1997

Activity of arysulfatase A in urine in children with urinary tract infection

Katarzyna Kiliś-Pstrusińska, Danuta Zwolińska, Ewa Bakońska-Pacoń, Krzysztof A. Sobiech

Med Sci Monit 1997; 3(3): CR346-349 :: ID: 501107


The urinary activity of arylsulfatase A (ASA), a lysosomal enzyme of proximal kidney tubules, was evaluated in children aged 6 to 16 with with a diagnosis of urinary tract infection (UTI). All patients had normal glomerular filtration rates (GFR); they were divided into 2 groups: I-with UTI only, II-with UTI and anomalies of urinary tract. Similar measurements of ASA activity were obtained for a control group of healthy children - group III. The ASA activity was compared with N-acetyl-beta-D-glucosaminidase (NAG) activity and beta-2-microglobulin (B2M) concentrations in urine - these compounds being presumed markers of damage to proximal kidney tubules. An increased ASA activity was observed in both groups of studied patients with UTI. Those found in group II children were the highest and were statistically significantly elevated above controls. There was also a positive correlation between ASA activity and NAG activity in these children. The results indicate the usefullness of measuring urinary ASA activity as a marker of proximal kidney tubule damage in children with UTI and structural anomalies of the urinary tract. There is also the implication that children with UTI and these anomalies are more susceptible to damage to the proximal tubules.

Keywords: urinary ASA, urinary tract infection, damages of nephron proximal tubules, urinary NAG

Add Comment 0 Comments


01 July 2024 : Editorial  

Editorial: The Global Threats of Increasing Antimicrobial Resistance Require New Approaches to Drug Development, Including Molecular Antimicrobial Adjuvants

Dinah V. Parums

DOI: 10.12659/MSM.945583

Med Sci Monit 2024; 30:e945583


In Press

Clinical Research  

Ultrasound-Guided PRP and SVF Therapy Shows Sustained Improvement in Severe Knee Osteoarthritis: A 12-Month...

Med Sci Monit In Press; DOI: 10.12659/MSM.943975  

Clinical Research  

Olfactory Dysfunction as a Marker for Cognitive Impairment in General Paresis of the Insane: A Clinical Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944243  

Clinical Research  

Endoscopic and Microscopic Tympanoplasty for Adhesive Otitis Media: A Comparative Prospective Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.945152  

Clinical Research  

Status of Professional Identity, Self-Directed Learning Competence, and Self-Efficacy Among Central Sterile...

Med Sci Monit In Press; DOI: 10.12659/MSM.944044  

Most Viewed Current Articles

17 Jan 2024 : Review article   4,462,997

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research   1,599,717

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research   691,092

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial   50,889

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750