Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 September 1997

Bowel ischaemia-reperfusion-induced liver and lung injury: the fundamental role of Eicosanoids and Xanthine oxidase-generated oxygen free radicals

Avi A. Weinbroum, Gideon Goldman, Yoram Kluger, Masoud Hag, Sylvia Marmour, Patrick Sorkine, Joseph M. Klausner, David Niv, Valery Rudick

Med Sci Monit 1997; 3(5): BR624-630 :: ID: 501505

Abstract

Background: The aim of the study was to assess complementary induction of remote organ injury following bowel ischaemia- reperfusion by eicosanoids and xanthine oxidase.
Material/Methods: Randomized, controlled, animal study. Hospital-based animal research facility. Materials: 40 rats in 5 groups. Sham laparotomy, laparotomy and superior mesenteric artery occlusion (ischaemia 1h) and reperfusion (3h), or laparotomy and arterial occlusion and reperfusion in rats treated with thromboxane synthase inhibitor OKY-046, leukotrienes synthase inhibitor diethylcarbamazine or xanthine oxidase inhibitor allopurinol. Bowel, liver and lung wet: dry weight ratio, tissue: circulation albumin I125, permeability index, polymorphonuclear neutrophils tissue counts.
Results: Ischaemia intestinal and lungs wet: dry ratios increased by 50%; over sham or treatment groups; liver ratios were similar. Albumin indexes in ischaemia organs were 1.5-3 times more than shams and treatment values, and allopurinol normalized it best. Neutrophils counts in all ischaemia organs were double that of shams; allopurinol prevented sequestration completely, eicosanoids inhibitors did so partially.
Conclusions: Xanthine oxidase initiated remote organ injury following bowel ischaemia-reperfusion. Allopurinol prevented it entirely while eicosanoids inhibitors only partially.

Keywords: ischaemia-reperfusion, bowel, remote organ injury, thromboxane, leukotriene, Xanthine Oxidase, oxygen free radicals

0 Comments

Editorial

15 August 2022 : Editorial  

Editorial: The Metabolic (Dysfunction) Associated Fatty Liver Disease (MAFLD)-Non-Alcoholic Fatty Liver Disease (NAFLD) Debate: A Forced Consensus and The Risk of a World Divide

Nahum Méndez-Sánchez, Ming-Hua Zheng, Takumi Kawaguchi, Shiv K. Sarin
Liver Research Unit, Medica Sur Clinic & Foundation and Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico

DOI: 10.12659/MSM.938080

Med Sci Monit 2022; 28:e938080

In Press

12 Aug 2022 : Clinical Research  

Risk Factors and Pathogen Spectrum in Continuous Ambulatory Peritoneal Dialysis-Associated Peritonitis: A S...

Med Sci Monit In Press; DOI: 10.12659/MSM.937112  

11 Aug 2022 : Meta-Analysis  

Optimal Surgical Treatment Method for Anterior Cruciate Ligament Rupture: Results from a Network Meta-Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.937118  

10 Aug 2022 : Review article  

Programmed Cell Death in Diabetic Nephropathy: A Review of Apoptosis, Autophagy, and Necroptosis

Med Sci Monit In Press; DOI: 10.12659/MSM.937766  

10 Aug 2022 : Database Analysis  

Use and Effects of Augmentation of Labor with Oxytocin: A Single-Center, Retrospective, Case-Control Study ...

Med Sci Monit In Press; DOI: 10.12659/MSM.937557  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750