Abstract

The present study was undertaken to define the effects of streptokinase combined with nadroparin calcium (Fraxiparine) as compared with streptokinase combined with heparin in the treatment of myocardial infarction. The study population consisted of 86 patients with acute myocardial infarction randomized into a group given streptokinase and nadroparin calcium (45 patients) and a group treated with streptokinase and heparin (41 patients). The patients were evaluated with respect to the rate of enzyme changes, electrocardiographic and echocardiographic changes, the rate of reinfarctions, rhythm disorders, hemorrhagic complications and mortality. Patients treated with nadroparin calcium showed an earlier peak activity of CK, CKMB and myoglobin concentration than controls. In the same group there were also more patients with 50% reduction of the sum of ST segment elevations after 2 hours of therapy. Both groups did not differ in the peak activity of enzymes, the frequency of left ventricular thrombus, severe arrhythmias, reinfarctions and hemorrhagic complications. Ejection fraction was insignificantly higher in those treated with nadroparin calcium and mortality in the patients given heparin.The present results seem to indicate higher frequency of myocardial reperfusion in patients treated with streptokinase and nadroparin calcium than in those treated with streptokinase and heparin.

Keywords: thrombolysis, Streptokinase, Heparin, creatine kinase