Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 September 1997

Antimicrobial susceptibility of common bacterial pathogens isolated from lower respiratory tract infections in Poland in 1996 - the Alexander Project

Krzysztof Trzciński, Waleria Hryniewicz, The Alexander Project Collaborative Group

Med Sci Monit 1997; 3(5): EP714-722 :: ID: 501672

Abstract

In 1996, the Alexander Project, an international multi-centre study on the antimicrobial susceptibility of bacterial pathogens isolated from community-acquired lower respiratory tract infections (LRTI) commenced in Poland. Altogether 506 bacterial isolates were collected from sputum, broncho-alveolar and blood samples taken from patients diagnosed with LRTI. Of these, 262 were identified as Haemophilus influenzae (51.8% of all isolates), 154 as Streptococcus pneumoniae (30.4%), 60 as Moraxella catarrhalis (11.9%) and 30 as Staphylococcus aureus (5.9%). All strains were analysed according to their susceptibility to a wide set of antimicrobial agents by the broth microdilution method. Ten H. influenzae strains (3.8%) were identified as ampicillin-resistant, beta-lactamase-positive. In 6 other isolates (2.3%) lowered susceptibility to ampicillin without beta-lactamase production was detected, which may be indicate that these are ampicillin-resistant, beta-lactamase-negative (BLNAR) H. influenzae. Twenty two Streptococcus pneumoniae isolates (14.3%) were identified as penicillin non-susceptible pneumococci (PNSP). In this group of pneumococcal isolates, multi-drug resistance was observed. Among PNSP, only 18.2% were susceptible to doxycycline, 27.3% to co-trimoxazole, 36.4% to erythromycin, and 68.8% to chloramphenicol. Twelve (7.8%) PNSP isolates have been identified as intermediately susceptible to penicillin (MIC ranging from 0.12 to 1 mg/l) and all were susceptible to amoxicillin. Over 80% of M. catarrhalis and S. aureus isolates were beta-lactamase positive. Of the antimicrobial agents analysed over 90% of isolates were identified as being susceptible to ceftriaxone, amoxicillin with clavulanic acid, cefuroxime, ciprofloxacin and ofloxacin.
The Alexander Project is organised and funded by SmithKline Beecham.

Keywords: Alexander Project, lower respiratory tract infections, antibiotic resistance

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750