03 November 1997
Evaluating the relationship between social stress intensity and rapidity of carcinogenesis in an animal modelZygmunt Steplewski, Katarzyna Steplewska-Mazur, Grzegorz Mazur, Henryk Jaskołecki, Magdalena Elsner
Med Sci Monit 1997; 3(6): BR753-757 :: ID: 501723
Social stressors evolving from individual and population interactions produce stress reactions in many organisms (including humans), influencing homeostasis and altering the activity of the immunological system. Earlier reports showed that social stress, produced by altering social relations in breeding animals, accelerated the formation and growth of adenocarcinoma in rats. The objective of the present study was to identify relationships between intensity of the stress reaction, expressed as blood corticosterone concentrations, and the rapidity of adenocarcinoma growth in these rats. Sprague-Dawley rats were used for the studies. Stress reaction were induced through changes in g the roup relations of the rats' progeny after birth. The induction of adenocarcinoma was provoked chemically through DMBA administration or through inoculation of cultured neoplastic cells. Corticosterone concentrations were evaluated radioimmunologically. The rate of the neoplastic process was evaluated by weighing the dissected tumors. The results indicated that adenocarcinoma, induced chemically or through inoculation of tumor cells, develops faster in those animals which were separated from their mothers after termination of suckling and were then raised individually, than in those which remained with their mothers. The most rapid growth of adenocarcinoma was recorded in those animals which were separated from their mothers, kept in groups for a period of two weeks and then put into individual cages. Acceleration of carcinogenesis corresponded to the strength of the stress reaction, expressed as blood corticosterone concentrations. The results obtained imply a promoting effect of stress reactions upon carcinogenic processes. A possible responsible factor is the immunosuppresive effect of some components of the stress reaction, for instance corticosteroides.
Keywords: carcinogenesis, tumor, Corticosterone, Stress
01 May 2023 : EditorialEditorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy
Med Sci Monit 2023; 29:e940911
31 May 2023 : Review articlePrevalence, Diagnosis, and Management of Eclampsia and the Need for Improved Maternal Care: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.939919
30 May 2023 : Clinical ResearchA Case-Control Study of Cognitive Function in Patients with End-Stage Renal Disease Before and After Hemodi...
Med Sci Monit In Press; DOI: 10.12659/MSM.940409
30 May 2023 : Review articleA Review of the Role of the Zebrafish (Danio reiro) in Preclinical and Clinical Models of Biomarker Identif...
Med Sci Monit In Press; DOI: 10.12659/MSM.940550
30 May 2023 : Database AnalysisThe COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland
Med Sci Monit In Press; DOI: 10.12659/MSM.940904
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952