03 November 1997
Effectiveness of interferon alpha treatment in children of different ages with chronic hepatitis B
Dariusz Marek Lebensztejn, Maciej Kaczmarski, Maria Sobaniec-Łotowska, Dorota Sienkiewicz, Janusz SemeniukMed Sci Monit 1997; 3(6): PI932-936 :: ID: 501841
Abstract
The aim of the work was the evaluation of the interferon alpha (IFN) treatment in children of different ages with chronic hepatitis B. Observation was carried out on a group of 63 children with clinically and histopathologically diagnosed chronic hepatitis. 39 children out of this group (24 up to s years of age and 15 over 3 years old) with HBs and HBe antigenemia lasting for over 6 months were qualified for IFN treatment. The control group consisted of 24 children with cph without treatment. 12 months after IFN treatment termination in the subgroup of younger children regression of HBV DNA polymerase activity was observed in 54.4% of cases; 63.6% of children seroconverted to antiHBe, and 12.5% seroconverted to antiHBs as well. In the subgroup of older children regression of HBV DNA polymerase activity was observed in 50.0% of children and the same percentage seroconverted to antiHBe. In the control group 25.0% of untreated children seroconverted to antiHBe.
Keywords: children, interferon alpha, HBV infection, chronic hepatitis
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952