Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

03 November 1997

Humoral response in pulmonary tuberculosis

Anna Dubaniewicz

Med Sci Monit 1997; 3(6): RA956-960 :: ID: 501849

Abstract

Recent data provided by WHO and epidemiological analysis of Poland stress the decline in the regression rate of tuberculosis morbidity. It was found beyond any doubts that the cellular response is essential in the disease. Constant recirculation of T lymphocytes enables the repeated contacts of sensitised CD4+ T cells with specific antigen. Th1 and Th2 cells are activated by antigen what leads to the secretion of many cytokines. The optimal development of cellular response is usually accompanied by the lack of humoral response and vice versa. The constant stimulation by M. tuberculosis antigens leads not only to the T lymphocytes differentiation towards Th1 - Th2 population but also cause the activation of cells forming tuberculous granulation due to the lack of M. tuberculosis elimination. Under the stimulation of Mycobacterium antigens and cytokines secreted by monocytes, macrophages and Th2 lymphocytes, the plasmocytes clones able to antibodies production are formed by B lymphocytes. The concentration of immunoglobulins of differebt classes is not normal in patients suffering from tuberculosis which has been stressed by many authors. The increase of antibodies concentration in blood serum of patients is regulated by MHC. Immunoglobulins of A and G class form immunological complexes. There is also a correlation between the increased level of immunocomplexes in severe tuberculosis and the decrease of T cell activity and tissue damage. The storage of immunocomplexes in renal glomerules has been observed in severe tuberculosis. It is known that immunological complexes are able to activate the complement by classical or alternative pathway. The measurements and evaluation of particular complement fragments which has been performed by many authors, has revealed the increased concentration of C3 and C4 in active tuberculosis. In spite of this the role of the humoral response in the development and course of tuberculosis is not yet known.

Keywords: Tuberculosis, humoral response

Add Comment 0 Comments

Editorial

01 May 2024 : Editorial  

Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)

Dinah V. Parums

DOI: 10.12659/MSM.944927

Med Sci Monit 2024; 30:e944927

In Press

07 May 2024 : Clinical Research  

Treatment of AVN-Induced Proximal Pole Scaphoid Nonunion Using a Fifth and Fourth Extensor Compartmental Ar...

Med Sci Monit In Press; DOI: 10.12659/MSM.944553  

16 Mar 2024 : Clinical Research  

Diagnostic Efficiency of ACR-TIRADS Score for Differentiating Benign and Malignant Thyroid Nodules of Vario...

Med Sci Monit In Press; DOI: 10.12659/MSM.943228  

08 May 2024 : Clinical Research  

Effect of Individualized PEEP Guided by Driving Pressure on Diaphragm Function in Patients Undergoing Lapar...

Med Sci Monit In Press; DOI: 10.12659/MSM.944022  

21 Mar 2024 : Clinical Research  

Impact of Serum Vitamin D, B6, and B12 and Cognitive Functions on Quality of Life in Peri- and Postmenopaus...

Med Sci Monit In Press; DOI: 10.12659/MSM.943249  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750