Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

03 November 1997

Humoral response in pulmonary tuberculosis

Anna Dubaniewicz

Med Sci Monit 1997; 3(6): RA956-960 :: ID: 501849

Abstract

Recent data provided by WHO and epidemiological analysis of Poland stress the decline in the regression rate of tuberculosis morbidity. It was found beyond any doubts that the cellular response is essential in the disease. Constant recirculation of T lymphocytes enables the repeated contacts of sensitised CD4+ T cells with specific antigen. Th1 and Th2 cells are activated by antigen what leads to the secretion of many cytokines. The optimal development of cellular response is usually accompanied by the lack of humoral response and vice versa. The constant stimulation by M. tuberculosis antigens leads not only to the T lymphocytes differentiation towards Th1 - Th2 population but also cause the activation of cells forming tuberculous granulation due to the lack of M. tuberculosis elimination. Under the stimulation of Mycobacterium antigens and cytokines secreted by monocytes, macrophages and Th2 lymphocytes, the plasmocytes clones able to antibodies production are formed by B lymphocytes. The concentration of immunoglobulins of differebt classes is not normal in patients suffering from tuberculosis which has been stressed by many authors. The increase of antibodies concentration in blood serum of patients is regulated by MHC. Immunoglobulins of A and G class form immunological complexes. There is also a correlation between the increased level of immunocomplexes in severe tuberculosis and the decrease of T cell activity and tissue damage. The storage of immunocomplexes in renal glomerules has been observed in severe tuberculosis. It is known that immunological complexes are able to activate the complement by classical or alternative pathway. The measurements and evaluation of particular complement fragments which has been performed by many authors, has revealed the increased concentration of C3 and C4 in active tuberculosis. In spite of this the role of the humoral response in the development and course of tuberculosis is not yet known.

Keywords: Tuberculosis, humoral response

Add Comment 0 Comments

Editorial

01 November 2024 : Editorial  

Editorial: Artificial Intelligence (AI), Digital Image Analysis, and the Future of Cancer Diagnosis and Prognosis

Dinah V. Parums

DOI: 10.12659/MSM.947038

Med Sci Monit 2024; 30:e947038

0:00

In Press

Review article  

Comprehensive Insights into Arecoline Hydrobromide: Pharmacology, Toxicity, and Pharmacokinetics

Med Sci Monit In Press; DOI: 10.12659/MSM.945582  

Clinical Research  

Iliac Periosteal Bone Autografting vs Talus Non-Weight-Bearing Surgery in Hepple V Talus Osteochondral Inju...

Med Sci Monit In Press; DOI: 10.12659/MSM.944912  

Clinical Research  

Impact of Different Orthodontic Appliances on Mandibular Condyle, Anterior Region of Mandibular, and Maxill...

Med Sci Monit In Press; DOI: 10.12659/MSM.946265  

Clinical Research  

Risk Factors for Bone Cement Displacement After Percutaneous Kyphoplasty in Osteoporotic Vertebral Fracture...

Med Sci Monit In Press; DOI: 10.12659/MSM.945884  

Most Viewed Current Articles

17 Jan 2024 : Review article   6,371,831

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,909,013

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   695,468

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

07 Jan 2022 : Meta-Analysis   260,595

Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...

DOI :10.12659/MSM.935074

Med Sci Monit 2022; 28:e935074

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750