Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

30 October 1998

Enhancing effect of sodium taurocholate on stomach tumorigenesis induced by styrene oxide in Buffalo rats

Andrzej Bronowicz, Jerzy Rabczyński

Med Sci Monit 1998; 4(6): BR911-918 :: ID: 501888


Due to the constantly increasing hazard of styrene exposure and possible cocarcinogenesis in digestive tract with bilious acids, an experimental model of chronic exposure of stomach mucosa to styrene oxide [SO] with accompanying bilious reflux has been elaborated. In this study, 250 Buffalo rats were divided into four groups. The first experimental group E was fed with a control diet mixed with 0.25% sodium taurocholate [ST], and styrene oxide in vegetable oil, in concentration 200 mg/kg body weight. This was introduced into the stomach 3 times a week. The first control group C1 was fed with sodium taurocholate only, the second control group C2 was administered styrene oxide by gavage, and the third C3 received vegetable oil only. The experiment was carried out until natural death of the animals, and hence it has been completed after two years. The animals have been autopsied after death, and their organs have been taken for histologic examination. The results of stomach and forestomach examination have been then laid down to compare the frequency and intensity of occurring of particular features in groups, their coexistence, as well as the influence of survival upon their appearance. The results of this experiment show the potentializing effect of sodium taurocholate on the stomach carcinogenesis caused by styrene oxide. The influence of sodium taurocholate in the case of styrene oxide is not so strong as in the case of other carcinogens, what can result from the ability of styrene oxide, a non-polar compound, to penetrate the mucosa epithelium of the stomach and forestomach. In case of the carcinogens with a polar structure, occurring in the ionized form, the mucosa barrier becomes permeable only after it had been damaged by bile acids. The styrene dose, affecting dysplastic changes and carcinomas in stomach and forestomach in Buffalo rats, turned out to be a toxic dose, shortening the survival rate. The observed by us 5/138 cases of squamous carcinoma and 17/138 cases of dysplasia in the experimental group E have been accompanied by the 66/138 cases of papilla proliferation as well as by the acanthotic changes and basal layer hyperplasia in 38/138 and 52/138 cases, respectively.The results confirmed to the progression of the chemical carcinogenesis in rat's stomach, intensified by the activity of sodium taurocholate leading to carcinoma in the inflammatory changed mucosa via hyperplastic or dysplastic alterations. The results can be referred to ethiology and natural history of squamous esophageal carcinoma, and partially to Barrett esophagus with co-existing duodenal-gastro-esophageal reflux.

Keywords: styrene oxide, Bile Reflux, forestomach, carcinogenesis, Rat

Add Comment 0 Comments


01 June 2024 : Editorial  

Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals

Dinah V. Parums

DOI: 10.12659/MSM.945315

Med Sci Monit 2024; 30:e945315


In Press

Clinical Research  

Anterior Plate-Supported Cannulated Screw Surgery for Ankle Arthrodesis: Clinical and Radiologic Results in...

Med Sci Monit In Press; DOI: 10.12659/MSM.944452  

Clinical Research  

Elevated Plasma Levels of Growth Arrest Specific 6 (Gas6) Protein in Severe Obesity: Implications for Adipo...

Med Sci Monit In Press; DOI: 10.12659/MSM.944462  

Database Analysis  

Systemic Immune-Inflammation Index (SII) as a Predictor of Short-Term Mortality Risk in Sepsis-Associated A...

Med Sci Monit In Press; DOI: 10.12659/MSM.943414  

Clinical Research  

Morphological Variations of the Nasopalatine Canal in the North Cyprus Population: A Cone Beam Computed Tom...

Med Sci Monit In Press; DOI: 10.12659/MSM.944868  

Most Viewed Current Articles

17 Jan 2024 : Review article   2,131,100

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research   1,555,090

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research   690,471

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial   50,389

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750