Chronic character of GER resulting from inefficient antireflux mechanism may cause many non-typical clinical symptoms from different organs and systems of various intensity. Classical causes of the cough (e.g. allergy in patients with wheezing, cystic fibrosis and tuberculosis in the case of patients with chronic cough) should be excluded before the final diagnosis of GER as a cause of pathological symptoms is established.

Keywords: gastroesophageal reflux (GER), non-typical manifestation, diagnostic and therapeutic approach