Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 September 1998

Detection of specific IgM-CLASS antitreponemal antibodies in blood serum of patients with syphilis with the use of CAPTIA Syphilis-M reaction and comparing it with VDRL, FTA-ABS and TPHA reactions

Mieczysław Gibowski, Ryszard Żaba, Tatiana Machońko

Med Sci Monit 1998; 4(5): PI882-888 :: ID: 502060

Abstract

The aim of the study was to observe specific IgM-class antitreponemal antibodies in blood serum of patients with syphilis, with the use of immunoenzyme reaction CAPTIA Syphilis-M and to compare it with other routine syphilis serological reactions (VDRL, FTA-ABS and TPHA). The authors investigated the serum of the total of 200 patients with syphilis (123 men and 77 women), including 110 patients with early syphilis (not treated so far) and 90 patients with late syphilis (14 not treated subjects and 76 treated subjects). The patients were divided into subgroups depending on syphilis type. Examinations were performed with immunoenzyme reaction CAPTIA Syphilis-M and its results were compared with those obtained with the use of VDRL, FTA-ABS and TPHA reactions. Positive CAPTIA Syphilis-M results were observed in 90% of patients with early syphilis, and in only 11% of patients with late syphilis. As far as primary syphilis is concerned, this reaction was positive in 100% of subjects, while VDRL - in 56%, and TPHA and FTA-ABS - in 67% of cases. A slightly earlier negativity of CAPTIA Syphilis-M reaction when compared with VDRL was observed after therapy with penicillin. The authors presume that CAPTIA Syphilis-M is particularly useful in the diagnostics of early syphilis (especially primary syphilis) and that it is a more sensitive index of treatment efficiency than VDRL reaction.

Keywords: syphilis, serological reactions, CAPTIA Syphilis-M reaction

Add Comment 0 Comments

760 5

Editorial

01 December 2023 : Editorial  

Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory Infections

Dinah V. Parums

DOI: 10.12659/MSM.943312

Med Sci Monit 2023; 29:e943312

0:00

In Press

01 Dec 2023 : Clinical Research  

Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Clinical Research  

Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...

Med Sci Monit In Press; DOI:  

29 Nov 2023 : Clinical Research  

Comparative Analysis of Intramedullary Nail versus Plate Fixation for Fibula Fracture in Supination Externa...

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

0:00

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750