Abstract

Elevated levels of plasma lipoprotein(a) - Lp(a) have been considered a risk factor for premature atherosclerosis. Nowadays, it is a well-known fact that the beginning of atherosclerosis falls in childhood. The aim of the present study was to evaluate the concentrations of Lp(a) in children with simple obesity and/or hypertension, paying special attention to patients' family history of cardiovascular diseases. The study was carried out upon 35 children and youngsters aged 10-18. Out of 28 examined children, three groups of patients were formed: 10 with hypertension, 9 with obesity, 9 with both obesity and hypertension. Control group consisted of 7 children. Mean level of Lp(a) in the examined group was 60.1 mg/dl (ranging from 17 to 90 mg/dl) and it was statistically significantly higher than in the control group - mean level 24.4 mg/dl. The majority of children from the examined group presented a serious family history concerning risk factors of atherosclerosis. Lp(a) level was higher in children with positive family history of coronary heart disease when compared to the patients with negative history of this illness. There was a statistically significant, positive correlation between the concentration of Lp(a) and LDL cholesterol. Lp(a) should be regarded an independent risk factor of atherosclerosis in children and youngsters. Special prevention programme needs to be worked out for children with increased Lp(a) level and positive family history.

Keywords: children, Obesity, Hypertension, family history, Lipoprotein(a)