Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 May 1998

Malignant melanoma of the anal canal: choosing between abdomino-perineal resection or local excision

Marek P. Nowacki, Piotr Liszka-Dalecki, Janusz Olędzki, Rafał Sopyło, Maciej Chwaliński, Krzysztof Bujko, Anna Nasierowska-Guttmejer

Med Sci Monit 1998; 4(3): CR443-447 :: ID: 502424

Abstract

Records of 30 patients treated for malignant melanoma of the anal canal during the years 1948-96 were reviewed retrospectively. Most of them at the time of diagnosis were locally advanced - the median tumor diameter was 6.5 cm and the penetration of all tumors was deeper than 5 mm according to the Breslow classification. Surgery with intention of complete removal was performed on 25 of these patients and in 19 cases was considered to be microscopically complete: 7 abdominoperineal resections (APR) and 12 local excisions (LEX). Nine out of these 12 LEX were primarily done outside of our institution and can be considered only as excision biopsies. The median disease free survival time after APR was 4.25 month and after LEX was 9 month. Local recurrence was found in 4 out of 6 patients surviving after APR, and in 10 out of 12 after LEX. The median survival time after APR was 13 months, comparing with 21 months after LEX. Only one patient, a female, survived more than 5 years. She was treated by primary wide local excision, and the same procedure was done for her local recurrence. Two patients are still living 13 month after LEX + inguinal-iliac lymphadenectomy + radiation therapy without local recurrence or distant metastases. The authors support the hypothesis that survival of patients with malignant melanoma originating in the anal canal is not closely related to the aggressiveness of the primary surgery. The biology of the tumor and the clinical-pathological stage at presentation seem to be the most important prognostic factors. The authors believe that wide local excision should be recommended for all cases of 3 cm or less in diameter, and less than 3 mm of penetration according to the Breslow staging system. APR may be the procedure of choice for bigger and more penetrating lesions. Radiation therapy should be more widely employed, particularly in cases after LEX and in cases when primary surgery is contraindicated.

Keywords: anorectal melanoma, abdomino-perineal resection, local excision

Add Comment 0 Comments

Editorial

01 June 2024 : Editorial  

Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals

Dinah V. Parums

DOI: 10.12659/MSM.945315

Med Sci Monit 2024; 30:e945315

0:00

In Press

Clinical Research  

Epidemiology and Risk Factors for Revision Total Knee Arthroplasty in Chinese Patients: A Retrospective Stu...

Med Sci Monit In Press; DOI: 10.12659/MSM.943681  

Clinical Research  

Effects of the Cold Pressor Test on Popliteal Vein Diameter, Flow Velocity, and Blood Flow in the Lower Lim...

Med Sci Monit In Press; DOI: 10.12659/MSM.944560  

Clinical Research  

Outcomes of Anterior Lateral Approach and Gerdy's Tubercle Osteotomy for Tibial Plateau Fractures Involving...

Med Sci Monit In Press; DOI: 10.12659/MSM.943946  

Clinical Research  

Improving Function and Quality of Life in Patients with Chronic Neck Pain, Tension-Type Headache, and Forwa...

Med Sci Monit In Press; DOI: 10.12659/MSM.944315  

Most Viewed Current Articles

14 Dec 2022 : Clinical Research   1,494,766

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

17 Jan 2024 : Review article   1,476,009

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research   690,201

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial   50,159

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750