Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 May 1998

Relationship between polymorphism in the angiotensin converting enzyme gene and left ventricular volume and function in subjects below 50 years of age with an angiographically proven coronary heart disease

Dariusz Ciećwierz, Marcin Gruchała, Luther Keita, Adam Sukiennik, Waldemar Dorniak, Piotr Drewla, Wojciech Sobiczewski, Joanna Wdowczyk-Szulc, Karolina Ochman, Piotr Romanowski, Andrzej Rynkiewicz

Med Sci Monit 1998; 4(3): CR453-457 :: ID: 502447

Abstract

Introduction: Polymorphism in the angiotensin-converting enzyme (ACE) gene has been reported to correlate with circulating ACE concentration levels and to be associated with myocardial infarction, sudden death, ischemic and idiopathic dilated cardiomyopathy, restenosis following percutaneous transluminal coronary angioplasty and left ventricular hypertrophy. In the present study, we investigated the potential association between the insertion/deletion (I/D) polymorphism of the ACE gene and left ventricular volumes and function in relatively young patients with an angiographically proven coronary heart disease. Material and Method: The study was performed on forty patients with an angiograpically confirmed CHD, all being younger than fifty years of age (mean age 44(4 years, 36 males and 4 females). Left ventricular volumes and function were measured during cardiac catheterisation. The PCR technique was used to determine the ACE I/D genotype. [E1] Results: Allele frequencies in our study group were 39% for the I allele and 61% for the D allele. The observed genotype distribution was as follows: II=7/40, ID=17/40 and DD=16/40 and was in agreement with the Hardy-Weinberg equilibrium (p=0.99). No significant differences between the genotype groups were found for the main variables: age, body mass index, total cholesterol, LDL fraction cholesterol, HDL fraction cholesterol, tryglicerides, smoking habits, positive myocardial infarction, hypertension and diabetes history. A significant correlation between the DD genotype and the deterioration in left ventricular function was observed in the studied population. The ejection fraction in subjects with the DD genotype was significantly lower than in patients with ID or II genotypes (48±15% vs. 63±12%, p<0.01). Left ventricular end-diastolic pressure reflecting left ventricular diastolic function was significantly higher in DD genotype patients as compared to the ID+II group (16.3±6.8 mmHg vs. 11.9±3.7 mmHg, p<0.05). The stoke volume index in subjects with the DD genotype was significantly smaller than in the II+ID group (39±13 ml/m2 vs. 52±17 ml/m2, p<0.05). Conclusion: Our present study supports the hypothesis that the DD genotype is a marker of impaired left ventricular function in relatively young patients with coronary heart disease

Keywords: angiotensin-converting enzyme gene, coronary heart disease, left ventricular function, I/D polymorphism

Add Comment 0 Comments

Editorial

01 April 2024 : Editorial  

Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug Resistance

Dinah V. Parums

DOI: 10.12659/MSM.944600

Med Sci Monit 2024; 30:e944600

0:00

In Press

15 Apr 2024 : Laboratory Research  

The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in Osteoarthritis

Med Sci Monit In Press; DOI: 10.12659/MSM.943738  

0:00

07 Mar 2024 : Clinical Research  

Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...

Med Sci Monit In Press; DOI: 10.12659/MSM.943468  

0:00

08 Mar 2024 : Animal Research  

Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...

Med Sci Monit In Press; DOI: 10.12659/MSM.943443  

0:00

18 Apr 2024 : Clinical Research  

Comparative Analysis of Open and Closed Sphincterotomy for the Treatment of Chronic Anal Fissure: Safety an...

Med Sci Monit In Press; DOI: 10.12659/MSM.944127  

0:00

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750