Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 November 1999

Native tetanus and pertussis toxins effect on electrical and chemical seizures in mice

Roman Korolkiewicz

Med Sci Monit 1999; 5(6): BR1081-1089 :: ID: 503101


The tetanus toxin (Tetx) administered intracerebroventricularly (i.c.v.) or intraperitoneally (i.p.) caused the death of 50% of experimental mice (LD50,) at a dose of 18.0 (11.5-28.2) MLDs or 11.0 (8.3-14.6) MLDs/kg each. The minimal lethal dose (MLD) is defined as the lowest dose of Tetx required to kill a 20.0 g albino mouse within 96 hours following i.p. treatment [24]. Tetx increased the convulsive threshold of the electrical current and diminished particular chemical convulsant potencies. At the same time Tetx increased the protection given by a number of anti-epileptics during maximal electroshock treatment (MES). There were no marked γ-aminobutyric acid (GABA) concentration and total L-glutamic acid decarboxylase activity changes(GAD) in whole-brain homogenates accompanying Tetx treatment. These results suggest the preponderance of inhibitory over excitatory transmission probably due to Tetx action at the neuronal level. Tetx that penetrates into the central nervous system (CNS) following an i.p. injection evokes changes similar to those noted during Tetx administration into the lateral ventricle. Thus, both routes of adminstration demonstrate comparable predictive values in describing Tetx-induced changes during convulsive thresholds. Pertussis toxins (0.5 µg/animal, i.c.v., 120 h prior to testing), enhanced the chemical convulsants potency and decreased the carbamazepine protection during MES. It remained without marked influence upon the action of diphenylhydantoin and diazepam. These observations suggest that the enhanced sensitivity towards a number of chemical convulsants, irrespective of their action possibly results from a functional suppression of the inhibitory transmission at receptors coupled with pertussis toxin sensitive G proteins, rather than due to direct action on the G protein linked excitatory neurotransmission. The attenuation of carbamazepine efficacy might result in the sum of adenosine receptor antagonist drug properties and transmission suppression at the level of adenosine receptors coupled with G proteins sensitive towards pertussis toxins. Both toxins did not influence the total plasma levels of any anti-epileptic drug. Thus, the observed interactions between Tetx/pertussis toxins and anti-epileptic drugs probably occur at the neuronal level.

Keywords: Electroshock, Pertussis Toxin, Tetanus Toxin



04 June 2022 : Editorial  

Editorial: Acute Hepatitis of Unknown Origin in Children. Is Autoimmunity at Play?

Nahum Mendez-Sanchez, Shreya C. Pal
Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico

DOI: 10.12659/MSM.937371

Med Sci Monit 2022; 28:e937371


27 June 2022 : Clinical Research  

Shoulder Injury Related to Vaccine Administration (SIRVA) in 16 Patients Following COVID-19 Vaccination Who...

Med Sci Monit In Press; DOI: 10.12659/MSM.937430  

27 May 2022 : Clinical Research  

Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)

Med Sci Monit 2022; 28:e936547

In Press

28 Jun 2022 : Meta-Analysis  

Urodynamics in Early Diagnosis of Diabetic Bladder Dysfunction in Women: A Systematic Review and Meta-Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.937166  

28 Jun 2022 : Clinical Research  

Serum Calprotectin – a NET Product – as a Biomarker of Disease Activity in Patients with Systemic Lupus Ery...

Med Sci Monit In Press; DOI: 10.12659/MSM.936534  

28 Jun 2022 : Database Analysis  

LINC00963 May Be Associated with a Poor Prognosis in Patients with Cervical Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.935070  

27 Jun 2022 : Clinical Research  

Shoulder Injury Related to Vaccine Administration (SIRVA) in 16 Patients Following COVID-19 Vaccination Who...

Med Sci Monit In Press; DOI: 10.12659/MSM.937430  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750