01 November 1999
Selected parameters of cellular immunity in children with chronic hepatitis
Anna Szaflarska-Szczepanik, Mieczysława Czerwionka-Szaflarska, Grażyna Bała, Mariusz WysockiMed Sci Monit 1999; 5(6): CR1134-1139 :: ID: 503164
Abstract
The role of immune system in the pathogenesis of infections with hepatotropic viruses is still obscure. The aim of this work was to evaluate individual subpopulations of peripheral blood lymphocytes in children with chronic hepatitis. The study was conducted on 102 children (69 boys, 33 girls) aged 2-17 years with chronic virus hepatitis B (52 patients) and chronic virus hepatitis C (50 children), confirmed by serological and histopathological investigations. The subpopulations of peripheral blood lymphocytes were evaluated with standard techniques for immunofluorescent labelling of whole blood with flow cytometer Coulter EPICS XL 3C with the use of three sets of labelled antibodies (CD 3 / CD 19, CD 8 / CD 56, CD 3 / CD 4 / CD 8). 98% patients displayed anomalies within peripheral blood lymphocytes. The greatest disturbances were observed for NK cells and CD 4 lymphocytes Ð their levels decreased in 79.5% and 60.8% patients, respectively as well as CD 19 lymphocytes, whose percentage levels elevated in 61.5% patients. The level of lymphocytes with CD 3 phenotype was normal in the majority of children (81.4%), just as it was the case with the percentage of CD 8 lymphocytes and CD4:CD8 proportion which remained normal in nearly 54% patients. No significant differences were observed in mean levels of particular subpopulations of peripheral blood lymphocytes between children infected with various types of hepatotropic virus and with various intensification of histopathologic changes in the liver. Our findings confirm the involvement of non-specific defence mechanisms in the pathogenesis of chronic hepatitis.
key words: subpopulations of peripheral blood lymphocytes, chronic virus hepatitis C, chronic virus hepatitis B, children
Keywords: subpopulations of peripheral blood lymphocytes, chronic virus hepatitis C, chronic virus hepatitis B, children
537 0
Editorial
01 June 2023 : Editorial
Editorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic PreparednessDOI: 10.12659/MSM.941209
Med Sci Monit 2023; 29:e941209
In Press
05 Jun 2023 : Laboratory Research
Comparison of Composite Resin (Duo-Shade) Shade Guide with Vita Ceramic Shades Before and After Chemical an...Med Sci Monit In Press; DOI: 10.12659/MSM.940949
01 Jun 2023 : Clinical Research
Root Canal Numbers and Configurations in 1080 Permanent Canine Teeth in 270 Saudi Subjects Using Cone-Beam ...Med Sci Monit In Press; DOI: 10.12659/MSM.940472
01 Jun 2023 : Clinical Research
Internal Orifice Alloy Closure: A New Procedure for Treatment of Perianal Fistulizing Crohn’s DiseaseMed Sci Monit In Press; DOI: 10.12659/MSM.940873
01 Jun 2023 : Clinical Research
Effectiveness of Needle Aspiration versus Surgical Excision for Symptomatic Synovial Cysts of the Hip: A Si...Med Sci Monit In Press; DOI: 10.12659/MSM.940187
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952