Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 November 1999

Selected parameters of cellular immunity in children with chronic hepatitis

Anna Szaflarska-Szczepanik, Mieczysława Czerwionka-Szaflarska, Grażyna Bała, Mariusz Wysocki

Med Sci Monit 1999; 5(6): CR1134-1139 :: ID: 503164

Abstract

The role of immune system in the pathogenesis of infections with hepatotropic viruses is still obscure. The aim of this work was to evaluate individual subpopulations of peripheral blood lymphocytes in children with chronic hepatitis. The study was conducted on 102 children (69 boys, 33 girls) aged 2-17 years with chronic virus hepatitis B (52 patients) and chronic virus hepatitis C (50 children), confirmed by serological and histopathological investigations. The subpopulations of peripheral blood lymphocytes were evaluated with standard techniques for immunofluorescent labelling of whole blood with flow cytometer Coulter EPICS XL 3C with the use of three sets of labelled antibodies (CD 3 / CD 19, CD 8 / CD 56, CD 3 / CD 4 / CD 8). 98% patients displayed anomalies within peripheral blood lymphocytes. The greatest disturbances were observed for NK cells and CD 4 lymphocytes Ð their levels decreased in 79.5% and 60.8% patients, respectively as well as CD 19 lymphocytes, whose percentage levels elevated in 61.5% patients. The level of lymphocytes with CD 3 phenotype was normal in the majority of children (81.4%), just as it was the case with the percentage of CD 8 lymphocytes and CD4:CD8 proportion which remained normal in nearly 54% patients. No significant differences were observed in mean levels of particular subpopulations of peripheral blood lymphocytes between children infected with various types of hepatotropic virus and with various intensification of histopathologic changes in the liver. Our findings confirm the involvement of non-specific defence mechanisms in the pathogenesis of chronic hepatitis.
key words: subpopulations of peripheral blood lymphocytes, chronic virus hepatitis C, chronic virus hepatitis B, children

Keywords: subpopulations of peripheral blood lymphocytes, chronic virus hepatitis C, chronic virus hepatitis B, children

Add Comment 0 Comments

743 0

Editorial

01 December 2023 : Editorial  

Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory Infections

Dinah V. Parums

DOI: 10.12659/MSM.943312

Med Sci Monit 2023; 29:e943312

0:00

In Press

04 Dec 2023 : Animal Research  

Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mech...

Med Sci Monit In Press; DOI:  

01 Dec 2023 : Clinical Research  

Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Clinical Research  

Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

0:00

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750