01 November 1999
Med Sci Monit 1999; 5(6): CS1206-1212 :: ID: 503172
The aim of the study was to analyse the course of neutropenic typhlitis (NPT) in patients subjected to antineoplastic chemotherapy as well as to determine the value of imaging investigations such as ultrasonography and computerised tomography for the diagnosis of typhlitis and for treatment monitoring. We presented the course of NPT in 4 patients receiving high doses of cytosine arabinoside and methotrexate. All the patients displayed identical symptoms during neutropenia, such as fever, severe abdominal pain with vomiting and diarrhoea. In 2 patients, Clostridium difficile was detected during microbiological examination of faeces. Ultrasonography and computerised tomography of abdominal cavity revealed the expansion of intestinal loops with single fluid levels, the thickening of intestinal wall with narrowing of intestinal lumen, the absence of haustration in all the cases and hydroperitoneum in 2 children. No signs of intestinal perforation were observed. Due to the lack of indications for surgery, conservative treatment was introduced. The symptoms of typhlitis withdrew in 3 children, 1 child died because of dysrhythmia in the course of dyselectrolytaemia. The analysis of NPT course and the method of its treatment indicates that the use of oral therapy with metronidazole and vancomycin has a positive effect on the course of the disease, particularly in the case of concomitant infection with Clostridium difficile. Ultrasonography is a useful method for the diagnosis and monitoring the course of neutropenic typhlitis.
Keywords: chemotherapy, necrotic enteritis, typhlitis
04 June 2022 : EditorialEditorial: Acute Hepatitis of Unknown Origin in Children. Is Autoimmunity at Play?
Med Sci Monit 2022; 28:e937371
27 Jun 2022 : Clinical ResearchAutomatic Identification of Depression Using Facial Images with Deep Convolutional Neural Network
Med Sci Monit In Press; DOI: 10.12659/MSM.936409
23 Jun 2022 : Clinical ResearchA Real-World Study to Compare the Safety and Efficacy of Paritaprevir/Ombitasvir/Ritonavir and Dasabuvir, w...
Med Sci Monit In Press; DOI: 10.12659/MSM.936706
22 Jun 2022 : Clinical ResearchA Single-Center Study Comparing the Effects of Thoracic Spine Manipulation vs Mobility Exercises in 26 Offi...
Med Sci Monit In Press; DOI: 10.12659/MSM.937316
Most Viewed Current Articles
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Nov 2020 : Review articleLong-Term Respiratory and Neurological Sequelae of COVID-19
Med Sci Monit 2020; 26:e928996