01 November 1999
Med Sci Monit 1999; 5(6): RA1231-1237 :: ID: 503234
The current trends in healthy eating will increase levels of bulk-forming material in the diet, such as dietary fibre and other plant foods. Depending on the complex forming of such material the availability of absorbable calcium and other minerals may be impaired. It seems that non-digestible carbohydrates can inverse this effect. Major compounds belonging to this group are lactulose, fructo- and galacto-oligosaccharide and inulin. Lactose can only be regarded as a non-digestible carbohydrate in lactose-intolerant subjects and has been found not to affect or only minimally affect mineral absorption. The stimulation of mineral absorption by non-digestible carbohydrates takes place particularly in the ileum and the large intestine in different ways. An increase of passive transport mechanisms most likely occurs: one finding supporting the stimulation of passive mechanisms is that lactulose and calcitriol show additive action on calcium absorption. Degradation products of lactulose are SCFA which may stimulate transcellular transport of calcium. Whether or not active transport mechanisms are also involved in this process remains to be determined. pH in the distal ileum and the proximal colon is decreased by lactulose and other non-digestible carbohydrates. Increased calcium solubility by a reduced pH may increase paracellular calcium transport. Osmotic effects also may contribute to improved absorption of calcium and other minerals in that the 'tight junctions' become more permeable which may increase passive paracellular transport. Even though the mechanisms have not been fully elucidated, it can be said that lactulose enhances absorption of calcium and probably other minerals. The scale at which this occurs may be of clinical relevance in humans, particularly at an advanced age, since calcium absorption decreases during old age. Confirmatory studies will be needed to determine the significance of these results for the therapeutic or preventative use of lactulose in osteoporosis and other decalcification syndromes, and in colon cancer.
Keywords: calcium absorption, Lactulose
01 July 2022 : EditorialEditorial: World Health Organization (WHO) Variants of Concern Lineages Under Monitoring (VOC-LUM) in Response to the Global Spread of Lineages and Sublineages of Omicron, or B.1.1.529, SARS-CoV-2
Med Sci Monit 2022; 28:e937676
27 June 2022 : Clinical ResearchShoulder Injury Related to Vaccine Administration (SIRVA) in 16 Patients Following COVID-19 Vaccination Who...
Med Sci Monit In Press; DOI: 10.12659/MSM.937430
04 June 2022 : Clinical ResearchScreening for SARS-CoV-2 Infection in Students at the Medical University of Warsaw, Poland Between November...
Med Sci Monit 2022; 28:e936962
30 May 2022 : Clinical ResearchEffects of Wearing Face Masks on Exercise Capacity and Ventilatory Anaerobic Threshold in Healthy Subjects ...
Med Sci Monit 2022; 28:e936069
01 Jul 2022 : Clinical ResearchDoes Early-Period Patient Dissatisfaction Turn Into Satisfaction Over Time After Total Knee Replacement?
Med Sci Monit In Press; DOI: 10.12659/MSM.936792
30 Jun 2022 : Laboratory ResearchBcl-2 19-kDa Interacting Protein 3 (BNIP3)-Mediated Mitophagy Attenuates Intermittent Hypoxia-Induced Human...
Med Sci Monit In Press; DOI: 10.12659/MSM.936760
30 Jun 2022 : Clinical ResearchAntioxidant System and Ions Concentrations After Femoral Neck and Resurfacing Hip Arthroplasty
Med Sci Monit In Press; DOI: 10.12659/MSM.936335
Most Viewed Current Articles
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Nov 2020 : Review articleLong-Term Respiratory and Neurological Sequelae of COVID-19
Med Sci Monit 2020; 26:e928996