Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 1999

Immunogenetic aspects of coeliac disease in children

Anna Kędzierska

Med Sci Monit 1999; 5(4): CR732-740 :: ID: 504537

Abstract

The role of genetic factors predisposing to the occurrence of coeliac disease was supported by the demonstration of differences in the distribution of many genetic markers Ñ HLA system. The aim of the study was an attempt of genetic analysis of the existence of specific familial and allelic interrelationship in the secretion of certain class I HLA antigens (sHLA-I) in coeliac disease. The analysis included sHLA-I concentrations with reference to the associations between phenotype expression of certain HLA-I antigens (A1, B8) and disease manifestation. The study included: 425 serum samples obtained from children with coeliac disease (n=69), 319 serum samples obtained from their healthy siblings (n=49), 549 serum samples from probands' parents (n=91). Antigens HLA loci ABC were typed in a two-gradual microcytotoxic test according to NIH. Immunogenetic comparative analysis was related to the frequency of phenotypes and haplotypes in 1152 and 616 unrelated healthy persons, respectively. The following indices were determined: relative risk (RR) according to Svejgaard et al, etiologic fraction (EF, EFe) and preventive fraction (PF, PFE) according to Green. The level of sHLA-I determined in a semi-quantitative microabsorption test according to McLean et al. was compared with that obtained in 1515 sera of 248 persons forming control population. sHLA level for 13 antigens from locus A, 19 from locus B, 7 from locus C and markers of biallelic Bw4/Bw6 system was given as a sum of points of the inhibition of cytotoxic reaction. Positive associations  (p<0.0000...1) were observed for the following: HLA-A1, -B8,-Cw7, while negative associations were observed for HLA-A2. Haplotype HLA-A1-B8-Cw7 occurred significantly more frequently than in control group (p<0.000013Ð0.0000...1). There was a highly significantly lower
level of sHLA-ABC (p<0.0000...1) in sera of children with coeliac disease for: HLA-A1, A11, A32, B13, B27, B44, B51, Bw6, Cw1 and Cw3, while there was a significantly lower level of sHLA for sHLA-B38 (p<0.0052), B55 (p<0.0312) and Cw6 (p<0.0442). Significantly higher secretion was proved for sHLA-A23, Bw4 and Cw2. In the sera of siblings and parents, significantly lower differences of sHLA-I concentrations were observed in both cases for 3 antigens HLA-A (A11, A24, A32), 7 HLA-B (B13, B38, B39, B44, B51, B57, Bw6) and 3 HLA-C (Cw1, Cw3, Cw6). The detection of the presence of antigens HLA-A1, -B8 is a predisposing factor to the occurrence of hypersensitivity to gluten. Familial occurrence of decreased secretion of the same antigens may indicate the existence of common immunogenetic background for coeliac disease in this respect.

Keywords: soluble form of class I HLA antigens (sHLA-I), coeliac disease, HLA system, MHC

Add Comment 0 Comments

Editorial

01 November 2024 : Editorial  

Editorial: Artificial Intelligence (AI), Digital Image Analysis, and the Future of Cancer Diagnosis and Prognosis

Dinah V. Parums

DOI: 10.12659/MSM.947038

Med Sci Monit 2024; 30:e947038

0:00

In Press

Clinical Research  

Adipose-Derived Mesenchymal Stem Cells from Arthritis Patients: Differential Modulation of CD4⁺ T Cell Acti...

Med Sci Monit In Press; DOI: 10.12659/MSM.945273  

0:00

Review article  

Surgical Advances in the Treatment of Acromioclavicular Joint Injury: A Comprehensive Review

Med Sci Monit In Press; DOI: 10.12659/MSM.942969  

0:00

Clinical Research  

Analysis of Mortality Causes and Locations in Veterans with ALS: A Decade Review

Med Sci Monit In Press; DOI: 10.12659/MSM.945816  

0:00

Clinical Research  

Impact of Prior Cesarean Delivery on Pregnancy Outcomes and Hemorrhage Risks in Complete Placenta Previa: A...

Med Sci Monit In Press; DOI: 10.12659/MSM.944432  

0:00

Most Viewed Current Articles

17 Jan 2024 : Review article   6,511,914

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,913,219

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   695,669

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

07 Jan 2022 : Meta-Analysis   261,779

Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...

DOI :10.12659/MSM.935074

Med Sci Monit 2022; 28:e935074

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750