Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

30 April 1999

Electrophysiological evaluation of lidocaine effect on ion transport in airways in isolated trachea of rabbit

Artur Mościbroda, Bolesław Banach

Med Sci Monit 1999; 5(3): BR399-404 :: ID: 504727


Cough is a defence reflex removing harmful particles from airways outside the body. In vitro studies performed so far have proved that apart from reflex mechanisms, there is an ion mechanism adjunctive to cough. As the insertion of fibroscope to bronchial lumen triggers cough reflex, the aim of our study was to establish the effect of anaesthesia with lidocaine on ion reactions in airway epithelium, which would allow for their investigation in the future. The effect of compounds blocking nervous conduction (used in medicine as anaesthetic agents) upon the function of nerve and sensory endings of airway epithelial receptors is nearly completely obscure. Sensory endings play double role, i.e. they generate nervous afferent impulses and release locally-acting neuropeptides, while complex mutual interrelationships modulating both these functions were observed. Our study investigated the effect of lidocaine on two functionally different components of transepithelial electric potential (PD) of tracheal wall placed in modified Ussing apparatus. We took into consideration immediate lidocaine effects as opposed to its activity after 60-minute incubation in control conditions and after mechanical stimulation of epithelium. The results indicate that the effect of lidocaine on transepithelial potential depends on its duration and the mode of its delivery to the tissue. Lidocaine causes significant decline of spontaneous transepithelial potential (constant PD component), while it inhibits hyperpolarisation after mechanical stimuli (varying PD component) to lower extent. Depending on ion transport processes, the mechanisms of airway cleaning are not eliminated completely by lidocaine activity. Nervous sensory endings in airways influence cleaning processes and thus, these issues are of practical importance since local anaesthetics are used during diagnostic investigations as well as in the therapy of airway disturbances.

Keywords: in vitro studies, Ion Transport, Trachea, Lidocaine

Add Comment 0 Comments


01 May 2024 : Editorial  

Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)

Dinah V. Parums

DOI: 10.12659/MSM.944927

Med Sci Monit 2024; 30:e944927

In Press

Animal Research  

Enhanced Bone Healing Through Systemic Capsaicin Administration: An Experimental Study on Wistar Rats

Med Sci Monit In Press; DOI: 10.12659/MSM.942485  


Clinical Research  

Differential Inflammatory Responses in Adult and Pediatric COVID-19 Patients: Implications for Long-Term Co...

Med Sci Monit In Press; DOI: 10.12659/MSM.944052  

Clinical Research  

Effectiveness of Shoulder Taping in Treating Hemiplegic Shoulder Subluxation: A Randomized Controlled Study...

Med Sci Monit In Press; DOI: 10.12659/MSM.944222  

Clinical Research  

Comparison of Fentanyl, Ketamine, and Lidocaine Combined with Propofol Anesthesia in Patients with Crohn Di...

Med Sci Monit In Press; DOI: 10.12659/MSM.944116  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750