Logo Medical Science Monitor

Call: +1.631.470.9640
Closed: National Holiday

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 March 1999

Serum prolactin and sex hormone concentrations in patients with multiple sclerosis

Elżbieta Zych-Twardowska, Andrzej Wajgt

Med Sci Monit 1999; 5(2): CR216-220 :: ID: 505088

Abstract

Multiple sclerosis is considered to be a multifactoral disorder, with genetic, autoimmune, and environmental components. A few studies have indicated an influence of endocrine abnormalities on the pathogenesis of multiple sclerosis, and effect of demyelinization and therapy on hormonal system in this disease. The aim of this study was to evaluate endocrine function in patients with multiple sclerosis by an analysis of selected pituitary and sex hormones in blood. The study group consisted of 49 patients with multiple sclerosis, comprising 25 menstruating women, 6 postmenopausal women and 18 men. The pituitary-gonadal axis examination demonstrated normal serum concentration of gonadotropins and testosterone in women and men with multiple sclerosis, but we found raised serum concentration of estradiol in men with multiple sclerosis. There was statistically significant difference between multiple sclerosis and normal subjects. Our results confirm that hyperprolactinaemia frequently occurs in multiple sclerosis, especially in menstruating women and in men with multiple sclerosis. The results of this study suggest prevalence of hormonal disturbance in patients with multiple sclerosis, with regard to hyperprolactinaemia. In men with multiple sclerosis hyperprolactinaemia was associated with raised serum concentration of estradiol. Alterations in endocrine system in patients with multiple sclerosis may have essential significance for better understanding of etiopathogenesis and the course of disease. Presence of hormonal disturbances in these patients may be an indication for modifying the therapeutic proceeding.

Keywords: analysis, Hormones, Multiple Sclerosis

Add Comment 0 Comments

Editorial

01 June 2024 : Editorial  

Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals

Dinah V. Parums

DOI: 10.12659/MSM.945315

Med Sci Monit 2024; 30:e945315

0:00

In Press

Animal Research  

Targeting the Gut-Kidney Axis in Diarrhea with Kidney-Yang Deficiency Syndrome: The Role of Sishen Pills in...

Med Sci Monit In Press; DOI: 10.12659/MSM.944185  

Review article  

A New Pandemic of the XXIst Century: The Growing Crisis of Adolescent Depression in the Digital Age

Med Sci Monit In Press; DOI: 10.12659/MSM.944838  

Review article  

A Review of Wastewater-Based Epidemiology Studies for the Assessment of Over-the-Counter Medicines Used as ...

Med Sci Monit In Press; DOI: 10.12659/MSM.944120  

Clinical Research  

Functional Outcomes of Therapeutic Selective Nerve Root Block for Single-Segment Lumbar Spinal Stenosis: A ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943634  

Most Viewed Current Articles

17 Jan 2024 : Review article   1,652,499

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,522,350

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   690,265

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial   50,215

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750