01 April 2008
Transplantation of bone marrow mononuclear cells enables simultaneous treatment with osteotomy for osteonecrosis of the bilateral femoral headTakuma Yamasaki, Yuji Yasunaga, Hiroshi Terayama, Yohei Ito, Masakazu Ishikawa, Nobuo Adachi, Mitsuo Ochi
Med Sci Monit 2008; 14(4): CS23-30 :: ID: 850302
Background: Bone marrow derived mononuclear cells (BMMNCs) have the advantage of promoting both angiogenesis and osteogenesis. In this report, BMMNCs were transplanted into the affected area of one hip using interconnected porous calcium hydroxyapatite (IP-CHA) in two patients, while the other hip was simultaneously treated with transtrochanteric rotational osteotomy (TRO). This case report documents the potential of BMMNCs with IP-CHA for bone repair at the lesion of osteonecrosis of the femoral head.
Case Report: Two patients whose progression of osteonecrosis was stage 3 at one hip and stage 2 at the other hip. Firstly, TRO was performed on the collapsed side. Bone marrow aspirates were obtained from the iliac crest and were centrifuged with a cell separator during the procedure of TRO. BMMNCs were seeded into the IP-CHA and were transplanted to the lesion of osteonecrosis. Bone consolidation of transition zone on the cell-seeded femoral head was observed postoperatively at three or six months. The radiographs more than 22 months after surgery demonstrated shrinking of the extent of osteonecrosis, and no progression of collapse was observed.
Conclusions: We described two case reports of simultaneous surgical treatment for osteonecrosis of the bilateral femoral head using TRO for one hip in combination with transplantation of BMMNCs for the other hip. Short term results of this procedure are satisfactory without progression of collapse. Transplantation of BMMNCs may be a beneficial treatment for bone repair in the condition of osteonecrosis.
Keywords: Adolescent, Antigens, CD34 - metabolism, Bone Marrow Transplantation, Femur Head - surgery, Magnetic Resonance Imaging, Osteonecrosis - surgery, Osteotomy, Tomography, X-Ray Computed
01 December 2022 : EditorialEditorial: The World Health Organization (WHO) Fungal Priority Pathogens List in Response to Emerging Fungal Pathogens During the COVID-19 Pandemic
Med Sci Monit 2022; 28:e939088
29 November 2022 : Clinical ResearchRetrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...
Med Sci Monit In Press; DOI: 10.12659/MSM.938647
24 November 2022 : Clinical ResearchA Prospective Questionnaire-Based Study to Evaluate Factors Affecting the Decision to Receive COVID-19 Vacc...
Med Sci Monit In Press; DOI: 10.12659/MSM.938665
01 December 2022 : EditorialEditorial: The World Health Organization (WHO) Fungal Priority Pathogens List in Response to Emerging Funga...
Med Sci Monit 2022; 28:e939088
05 Dec 2022 : Database AnalysisImpact of the De Ritis Ratio on the Prognosis of Patients with Stable Coronary Artery Disease Undergoing Pe...
Med Sci Monit In Press; DOI: 10.12659/MSM.937737
02 Dec 2022 : Clinical ResearchValue of Early Laparoscopic Exploration for Primary Infertile Patients with Patent Fallopian Tubes Complica...
Med Sci Monit In Press; DOI: 10.12659/MSM.938637
02 Dec 2022 : Clinical ResearchSingle-Center Study in Lithuania to Evaluate the Role of Transthoracic Impedance Cardiography in the Diagno...
Med Sci Monit In Press; DOI: 10.12659/MSM.938389
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
01 Nov 2020 : Review articleLong-Term Respiratory and Neurological Sequelae of COVID-19
Med Sci Monit 2020; 26:e928996