27 October 2008
The preventive role of thoracic duct ligation on cerebral fat embolism in lung injury: an experimental studyMehmet Dumlu AydinABCDEFG, Atilla ErogluABCDEFG, Cemal GundogduABEFG, Atila TurkyilmazABEFG, Sare AltasABEFG, Nazan AydinABEFG
Med Sci Monit 2008; 14(11): BR256-260 :: ID: 869440
Cerebral fat embolism constitutes a major problem in intensive care units and treatment methods are highly controversial. Cerebral fat embolism has been thought to result from the migration of bone marrow fragments to the brain. However, the present authors observed that cerebral fat embolism is not possible unless the bone marrow particles cause alveolar wall destruction due to pulmonary artery occlusion. Thoracic duct ligation is essential for improved patient survival under such conditions. The aim was to investigate whether thoracic duct ligation plays a preventive role in cerebral fat embolism in lung injury.
Material and Method
Pulmonary contusion was established with chest wall trauma in 20 male hybrid rabbits (n=20), with thoracic duct ligation being administered to half (n=10). Ten days after the procedure, all the rabbits were sacrificed. Brain specimens were taken using the frozen-section method, stained with Sudan Black, and examined microscopically.
In the frozen brain sections the number of branches occluded by fat particles in both the central cerebral arteries was 15.5+/-3.02 in eight animals of the non-ligated group (GI) compared with 4.7+/-2.45 in two animals of the ligated group (GII). The number of occluded branches of the middle cerebral arteries was significantly higher in GI than in GII (p<0.001).
The number of branches of both central cerebral arteries occluded by lipid particles was greater in the non-ligated than in the ligated animals. It is believed that thoracic duct ligation provides significant protection against fat embolism in cases of thoracic trauma.
Keywords: Lung Injury - surgery, Intracranial Embolism - prevention & control, Embolism, Fat - prevention & control, Thoracic Injuries - surgery, Rabbits
01 May 2023 : EditorialEditorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy
Med Sci Monit 2023; 29:e940911
31 May 2023 : Review articlePrevalence, Diagnosis, and Management of Eclampsia and the Need for Improved Maternal Care: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.939919
30 May 2023 : Clinical ResearchA Case-Control Study of Cognitive Function in Patients with End-Stage Renal Disease Before and After Hemodi...
Med Sci Monit In Press; DOI: 10.12659/MSM.940409
30 May 2023 : Review articleA Review of the Role of the Zebrafish (Danio reiro) in Preclinical and Clinical Models of Biomarker Identif...
Med Sci Monit In Press; DOI: 10.12659/MSM.940550
30 May 2023 : Database AnalysisThe COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland
Med Sci Monit In Press; DOI: 10.12659/MSM.940904
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952