Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 December 2008

The relationship between NSAID use and osteoarthritis (OA) severity in patients with hip and knee OA: results of a case control study of NSAID use comparing those requiring hip and knee replacements to those in whom surgery was not recommended

Janet E. PopeABCDEFG, Kelly McCreaBCD, Adam StevensCD, Janine M. OuimetCDE

Med Sci Monit 2008; 14(12): CR604-610 :: ID: 869481

Abstract

Background
NSAIDs are not considered disease modifying in osteoarthritis (OA), though there has been debate that some may be chondroprotective and others chondrodestructive. We performed a case control study comparing NSAID use in subjects with hip or knee OA who had been treated surgically vs. medically. The purpose was to determine the relationship between NSAIDs and OA severity and if NSAIDs had a chondroprotective or chondrodestructive effect in our cohort.
Material and Method
The study population was subjects who were referred to orthopedic surgeons or rheumatologists and had no inflammatory arthritis or secondary OA. A questionnaire was mailed asking about current/ever use of specific NSAIDs. Between groups analyses were conducted for surgically treated cases vs. medically treated controls with mild, moderate and severe OA.
Results
Of 618 subjects, 73 had radiographic mild, 133 moderate and 412 severe OA. Surgically treated cases were less likely to have taken any NSAID (OR 0.44, 95% CI [0.23, 0.81], p<0.01. There was an inverse dose response with use of > or = 3 NSAIDs being taken in those with mild vs severe OA (OR 3.7), mild vs moderate OA (OR 2.5), and moderate vs severe OA (OR 1.5), all with p<0.0002; the same was found with > or = 2 NSAIDs, p<0.0002.
Conclusions
NSAID use and number of NSAIDs taken was greater in mild radiographic OA. We cannot support that some NSAIDs have negative cartilage effects from this study, and in fact, most NSAIDs were used in patients with less severe radiographic OA of the hip or knee.

Keywords: Osteoarthritis - surgery, Severity of Illness Index, Knee Joint - physiopathology, Hip Joint - physiopathology, Drug Utilization Review, Case-Control Studies, Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip, Anti-Inflammatory Agents, Non-Steroidal - therapeutic use

Add Comment 0 Comments

890 14

Editorial

01 November 2023 : Editorial  

Editorial: Factors Driving New Variants of SARS-CoV-2, Immune Escape, and Resistance to Antiviral Treatments as the End of the COVID-19 Pandemic is Declared

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville,

DOI: 10.12659/MSM.942960

Med Sci Monit 2023; 29:e942960

0:00

In Press

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Clinical Research  

Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...

Med Sci Monit In Press; DOI:  

29 Nov 2023 : Clinical Research  

Comparative Analysis of Intramedullary Nail versus Plate Fixation for Fibula Fracture in Supination Externa...

Med Sci Monit In Press; DOI:  

29 Nov 2023 : Clinical Research  

Impact of COVID-19 on Academic Burnout among Medical College Students in China: Findings from a Web-Based S...

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

0:00

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750