01 August 2008
Anti-hypertensive effects of a closed-loop chip system in renovascular hypertensive rats
Li-Min Zhou, Guo-Qing Zhu, Han-Jun Wang, Cong-Kan Zhao, Yao Xu, Xing-Ya GaoMed Sci Monit 2008; 14(8): BR153-158 :: ID: 869486
Abstract
Background
The authors' previous study showed a closed-loop chip system that was used to control arterial pressure in normal rabbits and rats. In the present study the anti-hypertensive effects of the chip system were investigated in anaesthetized two-kidney one-clip (2K1C) renovascular hypertensive rats and compared with sham-operated rats.
Material and Method
The chip system recorded, sampled, and processed the signals of arterial pressure and instantaneously controlled arterial pressure by stimulating the left aortic depressor nerve. The frequency of stimulation was determined according to the feedback signals of arterial pressure.
Results
The chip system, running three different programs, successfully achieved a different degree of depressor effects. It effectively decreased not only mean arterial pressure (MAP), but also renal sympathetic nerve activity (RSNA) in both 2K1C rats and sham-operated rats. The chip system significantly increased the baroreflex gain in the 2K1C rats, but not in the sham-operated rats. It normalized the increased left ventricle developing pressure and maximal rise rate of the left ventricle pressure (dP/dtmax) in the 2K1C rats.
Conclusions
These results indicate that the depressor effect can be controlled by changing the programs of the chip system. The closed-loop chip system effectively decreased arterial pressure and sympathetic outflow, increased baroreflex gain, and normalized the enhanced cardiac contractility in renovascular hypertensive rats.
Keywords: Renal Circulation - physiology, Sympathetic Nervous System - physiopathology, Rats, Inbred SHR, Myocardial Contraction - physiology, Implants, Experimental, Hypertension - therapy, Electric Stimulation, Blood Pressure - physiology, Baroreflex - physiology
612 1
Editorial
01 June 2023 : Editorial
Editorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic PreparednessDOI: 10.12659/MSM.941209
Med Sci Monit 2023; 29:e941209
In Press
08 Jun 2023 : Clinical Research
Risk Factors for New Vertebral Compression Fracture After Percutaneous Vertebral Augmentation: A Retrospect...Med Sci Monit In Press; DOI: 10.12659/MSM.940134
08 Jun 2023 : Clinical Research
A Nomogram for Identifying HR+/Her2- Breast Cancer Patients with Positive Sentinel Lymph Nodes and Omitted ...Med Sci Monit In Press; DOI: 10.12659/MSM.940124
08 Jun 2023 : Clinical Research
Burden of COVID-19 on Mental Health of Resident Doctors in PolandMed Sci Monit In Press; DOI: 10.12659/MSM.940208
08 Jun 2023 : Clinical Research
Risk Prediction for Rapidly Progressive Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis: Th...Med Sci Monit In Press; DOI: 10.12659/MSM.940251
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952