Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

21 February 2009

Beneficial effects of high dobutamine doses on hemodynamic perturbations induced by Buthus occitanus tunetanus venom in rats

Ahmed HakimABCDEF, Zouheir SahnounABDF, Hatem KallelCDEF, Mondher KassisBC, Mounir BouazizDFG, Khaled Mounir ZeghalADFG

Med Sci Monit 2009; 15(3): BR71-74 :: ID: 869577


Hemodynamic manifestations are the leading causes of death after scorpion sting. This study was performed to evaluate the dose-dependent effect of dobutamine on hemodynamic perturbations induced by Buthus occitanus tunetanus (Bot) scorpion venom in rats.
Material and Method
Bot venom (850 microg/kg) was administered intravenously. Five minutes later the animals were perfused with vehicle or dobutamine (5, 10, and 20 microg/kg/min). The effects of Bot and dobutamine treatment on systolic arterial pressure (SAP), diastolic arterial pressure (DAP), heart rate (HR), and survival of the rats were examined.
Bot venom caused a biphasic variation of SAP and DAP. These parameters reached their maximum values immediately after venom administration, followed by a substantial progressive fall. There was a remarkable decrease in HR, which never returned to its initial value. Dobutamine treatment proved to have significant effects on hemodynamic perturbations only in the group treated at the rate of 20 microg/kg/min. In these animals, the decreases in SAP, DAP, and HR were markedly less important after the 10th min after envenomation (P<0.05 vs. control). Survival rates between the groups showed a statistically significant difference (P<0.01). The rats receiving 20 microg/kg/min dobutamine showed the highest survival rate (P<0.05 vs. control).
Our results indicate that Bot venom (850 microg/kg) causes severe hemodynamic perturbations which were reversed only by high doses of dobutamine (20 microg/kg/min), demonstrating the necessity of adapting the dobutamine dose to the degree of envenomation gravity for optimizing its effect.

Keywords: Systole - drug effects, Scorpion Venoms - toxicity, Rats, Wistar, Dose-Response Relationship, Drug, Hemodynamics - drug effects, Dobutamine - pharmacology, Blood Pressure - drug effects

Add Comment 0 Comments


01 June 2024 : Editorial  

Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals

Dinah V. Parums

DOI: 10.12659/MSM.945315

Med Sci Monit 2024; 30:e945315


In Press

Database Analysis  

Comprehensive Analysis of Sphingolipid Metabolism-Related Genes in Osteoarthritic Diagnosis and Synovial Im...

Med Sci Monit In Press; DOI: 10.12659/MSM.943369  


Review article  

Applications of Functional Near-Infrared Spectroscopy (fNIRS) Neuroimaging During Rehabilitation Following ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943785  


Clinical Research  

Epidemiology and Risk Factors for Revision Total Knee Arthroplasty in Chinese Patients: A Retrospective Stu...

Med Sci Monit In Press; DOI: 10.12659/MSM.943681  

Clinical Research  

Effects of the Cold Pressor Test on Popliteal Vein Diameter, Flow Velocity, and Blood Flow in the Lower Lim...

Med Sci Monit In Press; DOI: 10.12659/MSM.944560  

Most Viewed Current Articles

14 Dec 2022 : Clinical Research   1,459,687

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


17 Jan 2024 : Review article   1,406,403

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


16 May 2023 : Clinical Research   690,139

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial   50,139

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750