Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

21 February 2009

Beneficial effects of high dobutamine doses on hemodynamic perturbations induced by Buthus occitanus tunetanus venom in rats

Ahmed HakimABCDEF, Zouheir SahnounABDF, Hatem KallelCDEF, Mondher KassisBC, Mounir BouazizDFG, Khaled Mounir ZeghalADFG

Med Sci Monit 2009; 15(3): BR71-74 :: ID: 869577

Abstract

Background
Hemodynamic manifestations are the leading causes of death after scorpion sting. This study was performed to evaluate the dose-dependent effect of dobutamine on hemodynamic perturbations induced by Buthus occitanus tunetanus (Bot) scorpion venom in rats.
Material and Method
Bot venom (850 microg/kg) was administered intravenously. Five minutes later the animals were perfused with vehicle or dobutamine (5, 10, and 20 microg/kg/min). The effects of Bot and dobutamine treatment on systolic arterial pressure (SAP), diastolic arterial pressure (DAP), heart rate (HR), and survival of the rats were examined.
Results
Bot venom caused a biphasic variation of SAP and DAP. These parameters reached their maximum values immediately after venom administration, followed by a substantial progressive fall. There was a remarkable decrease in HR, which never returned to its initial value. Dobutamine treatment proved to have significant effects on hemodynamic perturbations only in the group treated at the rate of 20 microg/kg/min. In these animals, the decreases in SAP, DAP, and HR were markedly less important after the 10th min after envenomation (P<0.05 vs. control). Survival rates between the groups showed a statistically significant difference (P<0.01). The rats receiving 20 microg/kg/min dobutamine showed the highest survival rate (P<0.05 vs. control).
Conclusions
Our results indicate that Bot venom (850 microg/kg) causes severe hemodynamic perturbations which were reversed only by high doses of dobutamine (20 microg/kg/min), demonstrating the necessity of adapting the dobutamine dose to the degree of envenomation gravity for optimizing its effect.

Keywords: Systole - drug effects, Survival Analysis, Scorpion Venoms - toxicity, Rats, Wistar, Dose-Response Relationship, Drug, Hemodynamics - drug effects, Dobutamine - pharmacology, Blood Pressure - drug effects

0 Comments

Editorial

01 October 2022 : Editorial  

Editorial: Rebound COVID-19 and Cessation of Antiviral Treatment for SARS-CoV-2 with Paxlovid and Molnupiravir

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.938532

Med Sci Monit 2022; 28:e938532

SARS-CoV-2/COVID-19

16 September 2022 : Review article  

Effects of Physiotherapy on Rehabilitation and Quality of Life in Patients Hospitalized for COVID-19: A Rev...

Med Sci Monit In Press; DOI: 10.12659/MSM.938141  

03 October 2022 : Clinical Research  

Effect of Vitamin D Concentration on Course of COVID-19

Med Sci Monit 2022; 28:e937741

In Press

30 Sep 2022 : Clinical Research  

Correlation Between Trough Level of Abiraterone and Prostate-Specific Antigen (PSA) Response in Metastatic ...

Med Sci Monit In Press; DOI: 10.12659/MSM.938091  

30 Sep 2022 : Review article  

A Review of the Biological Mechanisms of Dexmedetomidine for Postoperative Neurocognitive Disorders

Med Sci Monit In Press; DOI: 10.12659/MSM.937862  

29 Sep 2022 : Animal Research  

Effect of Antilogous Platelet-Rich Plasma on the Revascularization of Rabbit Prefabricated Flap

Med Sci Monit In Press; DOI: 10.12659/MSM.937718  

26 Sep 2022 : Clinical Research  

Distribution and Determinants of Plasma Homocysteine Levels in a Preconception Population: A Retrospective ...

Med Sci Monit In Press; DOI: 10.12659/MSM.937987  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750