Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

30 March 2009

Lower respiratory tract infections caused by Haemophilus influenzae: clinical features and predictors of outcome

Diamantis KofteridisADEF, George SamonisAEF, Elpis MantadakisE, Sofia MarakiB, George ChrysofakisB, Dimitrios AlegakisB, John PapadakisC, Achilleas GikasF, Demosthenes BourosAEF

Med Sci Monit 2009; 15(4): CR135-139 :: ID: 869612

Abstract

Background
We studied clinical features and predictors of outcome of lower respiratory tract infections caused by Haemophilus influenzae in hospitalized adults in a general hospital.
Material and Method
Medical records of hospitalized adults with H. influenzae lower respiratory tract infections during the period 1996 to 2002 were retrospectively reviewed using a standardized questionnaire.
Results
Eleven female (24%) and 34 male (76%) patients were identified. Median age was 68 years (range 28-86 years). Most patients had a smoking history (n=37; 82%) and an underlying medical condition, with chronic obstructive pulmonary disease being the most common (n=28; 62%). Pneumonia was diagnosed in 34 patients (76%). Among them, 10 (29%) showed lobar and 24 (71%) showed segmental opacification on chest radiograph. Parapneumonic pleural effusion was observed in 10 patients (22%). Fifteen patients (33%) had positive blood cultures for H. influenzae. Based on results of sputum, blood, and pleural cultures, empirical antibiotic regimens were appropriate in 40 patients (89%). Nonserotypeable H. influenzae accounted for the majority of cases (n=26; 58%). Thirty-six (80%) H. influenzae isolates were resistant to amoxicillin. Forty patients (89%) with infection had a favorable outcome. All 5 patients who died had pneumonia with respiratory failure and underlying disease. Linear logistic regression analysis revealed leukocytosis and cancer as independent risk factors of death.
Conclusions
H. influenzae lower respiratory tract infections were observed mainly in elderly patients with severe comorbidities. Pneumonia was associated with high mortality, especially in patients with underlying malignancy and H. influenzae isolates resistant to amoxicillin.

Keywords: Respiratory Tract Infections - pathology, Haemophilus Infections - pathology, Aged, 80 and over

Add Comment 0 Comments

Editorial

01 June 2024 : Editorial  

Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals

Dinah V. Parums

DOI: 10.12659/MSM.945315

Med Sci Monit 2024; 30:e945315

0:00

In Press

Clinical Research  

Trust and Support for Cancer Research Biobanks: Insights from Cancer Patients in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.944263  

Clinical Research  

Morphological and Dimensional Analysis of the Nasopalatine Canal: Insights from Cone-Beam Computed Tomograp...

Med Sci Monit In Press; DOI: 10.12659/MSM.944424  

Clinical Research  

Hemorrhagic Cysts in the Pancreas: Risk Factors, Treatment, and Outcomes – Insights from a Single-Center Study

Med Sci Monit In Press; DOI: 10.12659/MSM.941955  

Clinical Research  

Perioperative Administration of Tranexamic Acid and Low Molecular Weight Heparin for Enhanced Blood Managem...

Med Sci Monit In Press; DOI: 10.12659/MSM.944063  

Most Viewed Current Articles

14 Dec 2022 : Clinical Research   1,421,178

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

17 Jan 2024 : Review article   1,355,487

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research   690,090

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial   50,113

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750