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30 March 2009

Kinetics and prognostic value of inflammatory-sensitive protein, IL-6, and white blood cell levels in patients undergoing coronary stent implantation

Αntonios ZiakasABCDEFG, Stavros GavrilidisADF, George GiannoglouADF, Efthimia SouliouADF, Konstantinos KoskinasACDEF, Konstantinos GemitzisADF, Stavros HatzimiltiadisADF, George EfthimiadisADF, Stelios ParaskevaidisADF, Apostolos HatzitoliosADF, Christos SavopoulosADF, George ParharidisADF

Med Sci Monit 2009; 15(4): CR177-184 :: ID: 869618

Abstract

Background
The levels of interleukin-6 (IL-6), white blood cells (WBCs), and some inflammatory-sensitive proteins (ISPs), such as fibrinogen (FIB) and C-reactive protein (CRP), have been related to coronary stent restenosis. The aim was to investigate the time course of the levels of IL-6, WBC, and several ISPs, i.e. FIB, CRP, cerruloplasmin (CER), haptoglobin (HPT), alpha-1 antitrypsin (A1AT), and alpha-1 acid glycoprotein (A1GP), after successful coronary stenting in patients with stable angina and to relate them to prognosis.
Material and Method
FIB, CRP, IL-6, CER, HPT, A1AT, A1GP, and WBC levels were measured in 40 patients with stable angina before, and 6, 12, 24, 48, and 72 hours and 6 months after successful coronary stenting. The patients were followed up for 12 months.
Results
FIB levels increased significantly (p<0.05) 48 hours, CRP and WBC count 24 hours, CER, HPT, A1AT, and A1GP 72 hours, and IL-6 6 hours after stenting. All the levels remained unchanged in 20 control patients undergoing coronary angiography. During follow-up, stent restenosis occurred in 7 patients. Time-course and mean values of all the studied substances did not significantly differ in patients with or without restenosis (p>0.05).
Conclusions
FIB, CRP, IL-6, CER, HPT, A1AT, A1GP, and WBC levels increase significantly after stenting, but they are not related to prognosis.

Keywords: Leukocyte Count, Kinetics, Interleukin-6 - blood, Fibrinogen - metabolism, Coronary Disease - surgery, C-Reactive Protein - metabolism, Angioplasty, Prospective Studies, Stents

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