Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

29 May 2009

The significance of histological evidence of bile reflux gastropathy in patients with gastro-esophageal reflux disease

Andreas NakosAE, Petros ZezosC, Nikolaos LiratzopoulosB, Eleni EfraimidouG, Konstantinos ManolasD, John MoschosE, Epaminondas MolivasF, Georgios KouklakisA

Med Sci Monit 2009; 15(6): CR313-318 :: ID: 869681

Abstract

Background
Synergetic activity between acid and bile has been associated with extensive esophageal mucosal damage in patients with gastro-esophageal reflux disease (GERD). Reflux of bile causes injury to gastric mucosa evaluated with an established histological index (bile reflux index, BRI). The aim of the study was to investigate the role of bile reflux in patients with GERD using the BRI.
Material and Method
Fifteen asymptomatic subjects and 53 patients with GERD underwent upper gastrointestinal endoscopy with biopsies taken from the gastric antrum, body, cardia, and lower esophagus. The updated Sidney system was used for histological examination and BRI was calculated according to the findings in the antrum.
Results
BRI was elevated in 25/53 GERD patients (47%) and in 2/15 15 controls (13%) (OR: 5.8, 95%CI: 1.2-28.3). Elevated BRI was noted in 72% (13/18) of the patients with severe esophagitis (grade B or C) or Barrett's esophagus, whereas it was present in 34% (12/35) of those with mild or no lesions (OR: 5, 95%CI: 1.4-17.3). Additionally, 5 of the 6 patients detected with intestinal metaplasia (IM) at the cardia (83%) and 9 of the 12 patients with IM of the antrum (75%) had elevated BRI.
Conclusions
Bile reflux gastropathy is present in a significant proportion of patients with GERD and associated with disease severity. The elevated BRI in such patients highlights the role of duodeno-gastro-esophageal reflux as an additional factor in the pathogenesis of GERD.

Keywords: Gastroesophageal Reflux - pathology, Endoscopy, Demography, Bile Reflux - pathology, Aged, 80 and over, Adolescent

0 Comments

Editorial

01 March 2023 : Editorial  

Editorial: Global Surveillance of Highly Pathogenic Avian Influenza Viruses in Poultry, Wild Birds, and Mammals to Prevent a Human Influenza Pandemic

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939968

Med Sci Monit 2023; 29:e939968

SARS-CoV-2/COVID-19

29 March 2023 : Editorial  

Editorial: Effective Direct-Acting Antiviral Treatments Support Global and National Programs to Eliminate H...

Med Sci Monit In Press; DOI: 10.12659/MSM.940519  

30 March 2023 : Clinical Research  

An Online Survey on the Relationship Between Positive Coping and Post-Traumatic Stress Symptoms (PTSS) of M...

Med Sci Monit In Press; DOI: 10.12659/MSM.939485  

09 February 2023 : Clinical Research  

Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...

Med Sci Monit 2023; 29:e938892

In Press

30 Mar 2023 : Clinical Research  

An Online Survey on the Relationship Between Positive Coping and Post-Traumatic Stress Symptoms (PTSS) of M...

Med Sci Monit In Press; DOI: 10.12659/MSM.939485  

30 Mar 2023 : Database Analysis  

Global Research Trends and Hotspots in Lateral Epicondylitis During the Past 30 Years: A Bibliometric and V...

Med Sci Monit In Press; DOI: 10.12659/MSM.939309  

29 Mar 2023 : Editorial  

Editorial: Effective Direct-Acting Antiviral Treatments Support Global and National Programs to Eliminate H...

Med Sci Monit In Press; DOI: 10.12659/MSM.940519  

29 Mar 2023 : Laboratory Research  

Preparation, Physicochemical Properties, and Structural Characterization of Resistant Starch-Aspirin-Loaded...

Med Sci Monit In Press; DOI: 10.12659/MSM.939711  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750