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23 June 2009

The importance of antibiotic prophylaxis in GBS-positive parturient women

Milos Veleminsky Jr.ABCDEFG, Martina HrubesovaBDEF, Milan HanzlBD

Med Sci Monit 2009; 15(7): CR372-374 :: ID: 869713

Abstract

Background
Bacterial streptococcal colonization of the vagina of a pregnant woman can be transferred to her newborn and induce a septic disease. The aim was to emphasize the requirements of timely intrapartal administration of antibiotics to prevent the transfer of GBS strains to the newborn.
Material and Method
Three thousand two hundred seventy-eight pregnant women were evaluated who delivered babies during a 17-month period in 2006 and 2007 at the Department of Obstetrics and Gynecology in Ceské Budejovice. The results of their screening examinations from the 36th week of pregnancy were analyzed for information concerning their vaginal smears and smears from the newborns testing for GBS strains.
Results
The authors demonstrate that timely intrapartal administration of antibiotics considerably reduces the colonization of newborns with GBS strains (Fisher's exact test, p=0.0490).
Conclusions
It is necessary to adhere consistently to preventive provisions which lead to a reduction in the colonization of newborns with GBS strains. Late application, i.e. within four hours before parturition, statistically significantly increases the risk of colonization with GBS.

Keywords: Streptococcal Infections - microbiology, Pregnancy Complications, Infectious - microbiology, Pregnancy, Antibiotic Prophylaxis, Anti-Bacterial Agents - therapeutic use, Streptococcus agalactiae - physiology

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750