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01 August 2009

Psychological distress in Brazilian Crohn's disease patients: screening, prevalence, and risk factors

Maria Tereza BrandiABDE, Mário Sergio RibeiroADE, Liliana Andrade ChebliABDE, Márcio Bousada FrancoBF, André Luiz PintoBF, Pedro Duarte GaburriAF, Alexandre ZaniniACE, Julio Maria ChebliACDEG

Med Sci Monit 2009; 15(8): PH101-108 :: ID: 878123


Psychological disturbances are frequent in Crohn's disease (CD) patients. However, epidemiological studies of non-western CD populations are limited and may be confounded by genetic and disease-related influences. The aim of this study was to assess the prevalence and risk factors for depression and symptoms of anxiety in Brazilian patients with CD.
Material and Method
In this cross-sectional study, 110 CD patients and 110 control subjects with erosive esophagitis were assessed for depression and anxiety symptoms using the Beck Depression Inventory and the Hospital Anxiety and Depression Scale.
The Crohn's and control groups were similar with regard to socio-demographic data. Compared with the controls, the CD patients had a significantly higher prevalence of depressed mood (25.4% vs. 8.2%, P=0.003). There was no significant difference in the prevalence of anxiety between CD subjects (33.6%) and controls (22.7%). Depressed mood rates were higher among those who had active disease and greater CDAI scores (OR: 3.4, 95%CI 1.1-10.8). Family history of depression (OR: 5.3, 95%CI: 2.7-15.1) was related to the co-occurrence of anxiety symptoms.
In CD patients, depression and anxiety are highly concurrent conditions. Disease activity was strongly associated with depressed mood, while a family history of depression was related to anxiety. Screening for depression and anxiety should be carried out routinely as part of quality of care improvement in CD individuals.

Keywords: Mass Screening, Depression - epidemiology, Demography, Brazil - epidemiology, Crohn Disease - psychology, Anxiety - epidemiology, American Native Continental Ancestry Group - psychology, Adolescent, Risk Factors, young adult



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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750