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31 August 2009

Plasma sphingosine-1-phosphate concentration is reduced in patients with myocardial infarction

Malgorzata KnappAB, Marcin BaranowskiBCE, Dariusz CzarnowskiB, Anna LisowskaB, Piotr ZabielskiB, Jan GorskiADEFG, Wlodzimierz MusialB

Med Sci Monit 2009; 15(9): CR490-493 :: ID: 878180

Abstract

Background
The sphingolipid sphingosine-1-phosphate (S1P) plays an important role in protecting the heart against ischemia-reperfusion injury. S1P is normally present in human plasma. However, there are no data available on the effect of myocardial infarction on the plasma concentrations of S1P and related sphingolipids. The aim of this study was to examine the concentrations of S1P, sphinganine-1-phosphate, free sphingosine, free sphinganine, and ceramide in the plasma of patients after myocardial infarction.
Material and Method
The study was performed on two groups of male subjects: controls with no specific complaints (n=21) and patients who had had acute myocardial infarction (n=22). In the latter group, blood was taken immediately after admission to the hospital and five days later. The concentrations of the above compounds were measured by high-pressure liquid chromatography.
Results
The concentrations of S1P and sphinganine-1-phosphate were reduced by ca. 50% both early after infarction and five days later. The concentrations of the other compounds were not affected by myocardial infarction.
Conclusions
The reduction in plasma concentration of S1P after infarction could lessen its protective action on cardiomyocyte viability. The observed reduction in S1P level might be associated with the standard antiplatelet treatment given to patients since thrombocytes are one of the major sources of plasma S1P.

Keywords: Thrombolytic Therapy, Reperfusion Injury - prevention & control, Receptors, Lysosphingolipid - metabolism, Myocytes, Cardiac - metabolism, Myocardial Infarction - blood, Lysophospholipids - blood, Sphingosine - blood, Ceramides - metabolism

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750