Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

30 September 2009

Prolonged QT dispersion in children with congenital valvular aortic stenosis

Anna Piorecka-MakulaABCDEFG, Bozena WernerACDEG

Med Sci Monit 2009; 15(10): CR534-538 :: ID: 878215

Abstract

Background
Hypertrophied and ischemic cardiac muscle in patients with aortic valve stenosis becomes a potential source of ventricular cardiac arrhythmia that can lead to sudden death. Arrhythmia is associated with an abnormal duration of the action potential in a cardiac muscle cell. The aim of this prospective study was to analyze QT dispersion in children with different stages of aortic valve stenosis and different left ventricular mass indexes.
Material and Method
Sixty children with aortic valve stenosis were divided into 3 subgroups according to their pressure gradients. Sixty healthy children served as controls. Doppler echocardiography, standard 12-lead electrocardiography and 24-hour Holter monitoring electrocardiography were performed.
Results
QT dispersion was significantly higher in children with aortic stenosis than in the control group. There were statistically significant positive correlation between QT dispersion and left ventricular mass index and between QT dispersion and pressure gradient. QT dispersion was significantly higher in 20 patients with aortic stenosis and ventricular arrhythmia than that in patients without arrhythmia. In children with a higher pressure gradient and a higher left ventricular mass index, more complex arrhythmia was found.
Conclusions
Risk of ventricular arrhythmia increases with the degree of aortic valve stenosis and cardiac muscle hypertrophy. QT dispersion is prolonged in children with aortic valve stenosis, particularly in patients with arrhythmia, and increases with pressure gradient and left ventricular mass index.

Keywords: Heart Valves - physiopathology, Electrophysiological Phenomena, Heart Defects, Congenital - physiopathology, Case-Control Studies, Child, Heart Ventricles - physiopathology, Arrhythmias, Cardiac - physiopathology, Aortic Valve Stenosis - physiopathology, Organ Size

Add Comment 0 Comments

Editorial

01 November 2024 : Editorial  

Editorial: Artificial Intelligence (AI), Digital Image Analysis, and the Future of Cancer Diagnosis and Prognosis

Dinah V. Parums

DOI: 10.12659/MSM.947038

Med Sci Monit 2024; 30:e947038

0:00

In Press

Review article  

Comprehensive Insights into Arecoline Hydrobromide: Pharmacology, Toxicity, and Pharmacokinetics

Med Sci Monit In Press; DOI: 10.12659/MSM.945582  

Clinical Research  

Iliac Periosteal Bone Autografting vs Talus Non-Weight-Bearing Surgery in Hepple V Talus Osteochondral Inju...

Med Sci Monit In Press; DOI: 10.12659/MSM.944912  

Clinical Research  

Impact of Different Orthodontic Appliances on Mandibular Condyle, Anterior Region of Mandibular, and Maxill...

Med Sci Monit In Press; DOI: 10.12659/MSM.946265  

Clinical Research  

Risk Factors for Bone Cement Displacement After Percutaneous Kyphoplasty in Osteoporotic Vertebral Fracture...

Med Sci Monit In Press; DOI: 10.12659/MSM.945884  

Most Viewed Current Articles

17 Jan 2024 : Review article   6,371,831

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,909,013

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   695,468

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

07 Jan 2022 : Meta-Analysis   260,595

Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...

DOI :10.12659/MSM.935074

Med Sci Monit 2022; 28:e935074

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750