Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

19 October 2009

Prognostic significance of immunohistochemical Rac1 expression in survival in early operable non-small cell lung cancer

Kai YuanABCDEF, Chen QianAEFG, Ruheng ZhengAEG

Med Sci Monit 2009; 15(11): BR313-319 :: ID: 878233


The small GTPases are involved in the regulation of critical cellular functions, such as transcription control, cell cycle, and organization of actin cytoskeleton. Although a number of investigations have established the significance of Rho-family GTPases in several human tumors, there is still little information available on the clinical significance of Rac1 expression in non-small cell lung cancer (NSCLC). Therefore, immunohistologic expression of Rac1 was studied in a tissue microarray of 111 Stage I-II NSCLCs and correlated with clinicopathologic parameters and clinical outcome.
Material and Method
For this retrospective study 111 tissue samples, obtained from anonymized patients with early operable NSCLC (stage I-II), were used to construct a tissue microarray for immunohistochemical study.
Rac1 showed a cytoplasmic pattern of expression in tumor cells, while normal lung components showed negative or weak cytoplasmic staining. Rac1 expression increased significantly with the advancement of the T stage (P<0.01) and the TNM stage (P<0.05). Analysis of overall survival showed that Rac1 expression was related to poor outcome (P=0.012), even in the group of stage I patients (P=0.023). Multivariate analysis showed that Rac1 overexpression was an independent marker for overall survival after adjusting for other prognostic factors (P=0.023).
We found a positive prognostic value of immunohistologically determined Rac1 protein expression and presents Rac1 as a potential unfavorable prognosis biomarker in patients with early operable NSCLC.

Keywords: Neoplasm Staging, Proportional Hazards Models, Lung Neoplasms - surgery, Kaplan-Meier Estimate, Carcinoma, Non-Small-Cell Lung - surgery, rac1 GTP-Binding Protein - metabolism

Add Comment 0 Comments

821 15


01 November 2023 : Editorial  

Editorial: Factors Driving New Variants of SARS-CoV-2, Immune Escape, and Resistance to Antiviral Treatments as the End of the COVID-19 Pandemic is Declared

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville,

DOI: 10.12659/MSM.942960

Med Sci Monit 2023; 29:e942960


In Press

29 Nov 2023 : Laboratory Research  

CTRP13 Mitigates Endothelial Cell Ferroptosis via the AMPK/KLF4 Pathway: Implications for Atherosclerosis P...

Med Sci Monit In Press; DOI: 10.12659/MSM.942733  

28 Nov 2023 : Clinical Research  

Impact of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography on Therapeutic Decisions and ...

Med Sci Monit In Press; DOI: 10.12659/MSM.942122  

28 Nov 2023 : Clinical Research  

Long-Term Outcomes of Decompression and Grafting in Acute Pathological Proximal Femur Fractures in Children...

Med Sci Monit In Press; DOI: 10.12659/MSM.943031  

27 Nov 2023 : Clinical Research  

Comparison of Outcomes from Emergency Admissions to a Major Trauma Center in Turkey of 1646 Elderly Patient...

Med Sci Monit In Press; DOI: 10.12659/MSM.942916  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750