Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 February 2010

Bacterial colonization of pleural drains in patients with lung cancer: an analysis of risk factors

Izabela Korona-GlowniakABCDEF, Renata LosABEF, Pawel RybojadABD, Marek SawickiB, Anna MalmABCDEF

Med Sci Monit 2010; 16(2): CR84-91 :: ID: 878358

Abstract

Background
Microbial colonization of pleural drains during the postoperative period may be regarded as an important factor in infection development. The aim of this paper was to determine the frequency and risk factors associated with microbial colonization of pleural drains in patients with non-small-cell lung cancer (NSCLC) who underwent surgical resection.
Material and Method
A total of 72 pleural drain fluids obtained from 36 patients with NSCLC were microbiologically examined.
Results
Microbial colonization of pleural drain fluid was noted in 30/36 patients (83.34%). Aerobic and anaerobic bacteria were found in 13 (36.11%) and 7 (19.44%) patients, respectively, and mixed microflora were cultured from 9 (25%). Non-fermentative gram-negative rods and coagulase-negative staphylococci were mainly isolated. Univariate analysis revealed that FEV1% >65 and FEV1/FVC were significantly related to drain colonization by bacteria in general, FEV1/FVC to colonization by aerobic bacteria, and hospitalization >5 days before surgery to colonization by anaerobic bacteria. According to multivariate analysis, application of antibiotic prophylaxis other than cefuroxime or ceftriaxone and FEV1% >65 were the independent factors related to drain colonization by bacteria in general; antibiotic prophylaxis other than cefuroxime or ceftraixone alone and hospitalization >5 days before surgery to colonization by anaerobic bacteria; and a higher rate of FEV1/FVC, no chemotherapy before surgery, and postsurgical complications after surgery to colonization by aerobic bacteria.
Conclusions
Patients with resectable lung cancer showed a high rate of pleural drain colonization, mainly by opportunistic pathogens, even in the absence of clinical signs of infection.

Keywords: Pleural Cavity - microbiology, Multivariate Analysis, Lung Neoplasms - surgery, Drainage - adverse effects, Colony Count, Microbial, Carcinoma, Non-Small-Cell Lung - surgery, Bacteria, Aerobic - isolation & purification, Bacteria - isolation & purification, Risk Factors

Add Comment 0 Comments

Editorial

01 February 2025 : Editorial  

Editorial: Current Approaches to Screening for Lung Cancer in Smokers and Non-Smokers

Dinah V. Parums

DOI: 10.12659/MSM.948255

Med Sci Monit 2025; 31:e948255

0:00

In Press

Clinical Research  

Predicting Cerebral Small Vessel Disease Burden Based on Thromboelastography in Patients with Acute Ischemi...

Med Sci Monit In Press; DOI: 10.12659/MSM.946303  

Clinical Research  

Long-Term Outcomes of Implanon in Managing Adenomyosis: A 3-Year Prospective Study

Med Sci Monit In Press; DOI: 10.12659/MSM.945972  

Laboratory Research  

Linear Dimensional Accuracy in Maxillomandibular Records: A Comparative Study of Scannable and Transparent ...

Med Sci Monit In Press; DOI: 10.12659/MSM.947265  

Clinical Research  

Efficacy of King's Combined Uterine Suture in Managing Placenta Accreta: A Retrospective Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.945826  

Most Viewed Current Articles

17 Jan 2024 : Review article   6,969,932

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research   701,896

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Mar 2024 : Editorial   25,741

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ...

DOI :10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

28 Jan 2024 : Review article   20,253

A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and Future

DOI :10.12659/MSM.943912

Med Sci Monit 2024; 30:e943912

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750