Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

28 April 2010

Skeletal and heart muscle expression of PDGF-AA and VEGF-A after an acute bout of exercise and endurance training in rats

Bozena Czarkowska-PaczekABCDEFG, Malgorzata Zendzian-PiotrowskaBG, Irena BartlomiejczykBC, Jacek PrzybylskiFG, Jan GorskiBG

Med Sci Monit 2010; 16(5): BR147-153 :: ID: 878537

Abstract

Background
Physical exercise benefits the heart, but the mechanism is not understood. The mechanism of muscle plasticity after physical training is also unclear. The proangiogenic and mitogenic activity of PDGF and VEGF could be involved in both processes. This study investigated the influence of a single bout of acute exercise on the PDGF-AA and VEGF-A expression in skeletal and heart muscle in untrained rats and in those subjected to prolonged endurance training (trained).
Material and Method
Fifty-nine rats were randomly assigned to the untrained (UT) or trained (T, subjected to 6-week endurance training) groups. The groups were subjected to an acute bout of exercise with the same work load a day after final training. Rats of both groups were sacrificed and skeletal and heart muscle samples were collected before, immediately after (0 h), or 3 hours (3 h) after acute exercise.
Results
Prolonged training caused an increase in PDGF-AA mRNA (p=0.038) and protein (p=0.016) in rat skeletal muscle (T vs. UT). A similar pattern was observed in VEGF-A, but the changes were not significant. Acute exercise caused a significant decrease in PDGF-AA mRNA after 0 and 3 h (p=0.03 and p=0.04, respectively). In the heart there were no significant changes in either mRNA after acute exercise or after endurance training.
Conclusions
Six-week endurance training in rats increases PDGF-AA mRNA and protein in skeletal, but not in heart muscle.

Keywords: Reverse Transcriptase Polymerase Chain Reaction, Rats, Wistar, RNA, Messenger - genetics, Platelet-Derived Growth Factor - metabolism, Myocardium - metabolism, Physical Conditioning, Animal, Bone and Bones - metabolism, Vascular Endothelial Growth Factor A - metabolism

Add Comment 0 Comments

Editorial

01 April 2024 : Editorial  

Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug Resistance

Dinah V. Parums

DOI: 10.12659/MSM.944600

Med Sci Monit 2024; 30:e944600

0:00

In Press

04 Mar 2024 : Clinical Research  

Injury-Admission Time is an Independent Risk Factor for Deep Vein Thrombosis in Older Patients with Osteopo...

Med Sci Monit In Press; DOI: 10.12659/MSM.943587  

0:00

04 Mar 2024 : Clinical Research  

Evaluation of the Interrater Reliability of Sonographic Measurements of Muscle Thickness of 38 Piriformis M...

Med Sci Monit In Press; DOI: 10.12659/MSM.943720  

0:00

05 Apr 2024 : Clinical Research  

Comparative Analysis of Transoral Endoscopic Parathyroidectomy Vestibular Approach and Focused Open Surgery...

Med Sci Monit In Press; DOI: 10.12659/MSM.944128  

05 Mar 2024 : Clinical Research  

Muscular Function Recovery from General Anesthesia in 132 Patients Undergoing Surgery with Acceleromyograph...

Med Sci Monit In Press; DOI: 10.12659/MSM.942780  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750